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. 2025 Aug 26;15(36):29627–29645. doi: 10.1039/d5ra03313f

Table 13. The anti-ZIKV activity of the compounds 204–206.

Compd ZIKV reporter assay Titer reduction assay CC50 (μM)
Inhibition (%) at 10 μM Viability (%) at 10 μM EC50 (μM) % at 8.5 μM % at 1.5 μM EC50 (μM) EC90 (μM) EC99 (μM)
204 73 69 5.25 93 5.21 10.7 20.0
205 78 68 4.10 97 47 4.29 9.02 13.6 20.6
206 90 60 3.16 99 5.05 6.98 12.7 5.3