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. 2025 Aug 26;15(36):29627–29645. doi: 10.1039/d5ra03313f

Table 13. The anti-ZIKV activity of the compounds 204–206.

Compd ZIKV reporter assay Titer reduction assay CC50 (μM)
Inhibition (%) at 10 μM Viability (%) at 10 μM EC50 (μM) % at 8.5 μM % at 1.5 μM EC50 (μM) EC90 (μM) EC99 (μM)
204 73 69 5.25 93 — 5.21 10.7 — 20.0
205 78 68 4.10 97 47 4.29 9.02 13.6 20.6
206 90 60 3.16 99 — 5.05 6.98 12.7 5.3