Table 5. DHFR inhibition activity for compound 175 and TMP.
| Compd | IC50 (μM) | |||
|---|---|---|---|---|
| S. aureus DHFR | P. berghei DHFR | E. coli DHFR | N. gonorrhoeae DHFR | |
| 175 | 0.039 | 0.41 | 0.44 | 0.18 |
| TMP | 0.047 | 0.24 | 0.007 | 0.45 |
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