Table 7. The ability of compounds 179–186 to bind GyrB/ParE.

Compd	K i (nM)		K i (nM)		K i (nM)
	F. tularensis GyrB	F. tularensis ParE	E. coli GyrB	E. coli ParE	E. faecalis GyrB	E. faecalis ParE
179	<0.3	0.6	<0.3	1.1	—	—
180	<0.3	2.5	<0.3	1.7	—	—
181	<0.3	1.8	0.4	3.4	—	—
182	<0.3	0.6	<0.3	0.9	—	—
183	<0.3	1.1	<0.3	4.6	—	—
184	520	856	350	536	650	408
185	<0.3	<0.4	<0.05	<0.1	<0.3	<0.3
186	<0.3	0.8	0.3	0.9	<0.3	<0.3