Table 2.

Mutations clinically associated with liver diseases.

	Immune escape mutations	Liver cirrhosis-associated mutations	Chronic hepatitis-associated mutations	HCC-associated mutations	FH-associated mutations
preS1		W4P	W4P	W4P H51Q
preS2		F141L M120I		F141L M120I
S	sL21S sR24K sI68T sC76Y sL77R sF80S sF85C sL95W sL98V sM103I sI110L sS113T sK122R sT126A sL126S sT127P sA128V sM133L sG145A sA159V sY161F sS167L
Core promoter				1613G > A 1653 C > T 1674T > C 1752 A > G 1753T > A/G/C 1762 A > T/1764G > A 1766 C > G/T	1754T > G 1762 A > T/1764G > A
Precore/core		1753T/1899G 2441T > C (S183P)	2441T > C (S183P)	1814 A > C 1858T > C 1862G > T 1915G > A 2002 C > A 2159 A > G 2189 A > C (cI97L) 2189 A > T (cI97F) 2444 C > T (cQ182*)	1896G > A 1753T/1896G 1899G > A
X				H94Y I127V/T/M/L I127N/S/T K130M/V131I