Table 3.

Frequency of clinically relevant mutations according to HBV genotype.

	Genotype A (n = 7)	Genotype B (n = 9)	Genotype C (n = 15)	Genotype D (n = 1)
Immune escape mutations
S	sR24K sI68T sC76Y sF85C sM103I: 28.6% sI110L sS113T sA128V sS167L	sL21S sC76Y sL95W sK122R sT126A: 77.8% sM133L sG145A sA159V sY161F	sF20S sI68T sL77R sF80S: 53% sL95W sL98V sl126S	sV118T sT127P: 100% sV128A
Liver cirrhosis-associated mutations
preS2	F141L: 14.3%		M120I: 6.7%
Chronic hepatitis-associated mutations
preS1		W4P: 11.1%
precore/core	2441T > C (S183P) : 28.6%
HCC-associated mutations
preS2	F141L: 14.3%		M120I: 6.7%
Core promoter	1653 C > T: 14.3%	1613G > A: 11.1% 1752 A > G/1753T > G/1754T > G: 55.6% 1762 A > T/1764G > A: 11.1%	1613G > A: 6.7% 1653 C > T : 13.3% 1674T > C: 6.7% 1753T > A/G/C: 20% 1753/1896: 6.7% 1762 A > T/1764G/A: 46.7% 1764G/A: 6.7% 1766 C > G/T: 13.3%	1752 A > C 100% 1766 C > G 100%
Precore/core	1814 A > C (eM1*) : 14.3% 1858T > C: 71.4% 1862G > T: 14.3% 2441T > C (S183P) : 28.6%	1858T > C: 22.2% 1896G > A: 55.6% 1899G > A: 11.1% 1915 C > G: 22.2% 2002 C > T: 66.7% 2189 A > C (cI97L) : 22.2% 2189 A > T (cI97F) : 11.1% 2441T > C (cS181P) : 55.6%	1896G > A: 20% 1899G > A: 13.3% 1915G > A: 6.7% 2002 C > A: 6.7% 2159 A > G: 13.3% 2189 A > C (cI97L) : 40% 2444 C > T (cQ182*): 6.7% 2441 A > C (cS181P) : 6.7%	1915T > A: 100%
X	H94Y: 14.3%	I127V/T/M: 55.6% K130M/V131I: 11.1%	H94Y: 13.3% I127N/S/T: 20% V131I: 6.7% K130M/V131I: 46.7%	I127L: 100%
FH-associated mutations
preS1		W4P: 11.1%	H51Q: 13.3%
Core promoter		1754T > G: 33.3% 1762 A > T/1764G > A: 11.1%	1762 A > T/1764G/A: 46.7%
Precore/core		1896G > A: 55.6%	1896G > A: 20%