Table 5.

Comparison of advantages and disadvantages of different CPS

CPS	CPB	m-CPB	VA-ECMO	VV-ECMO
Hemodynamic support	full support	full support lower, but with risk of hemodynamic instability due to blood loss and insufficient drainage	full support lower, but with risk of hemodynamic instability due to blood loss and insufficient drainage	no, with risk of hemodynamic instability due to blood loss
Respiratory support	full support	partial support due to native cardiac output	partial support due to native cardiac output	full support
Recirculation	no	no	no	yes
Harlequin syndrome	no	yes	yes	no
Oxygen delivery	full	full	full	barely enough
Hemodilution	higher	moderate	lower	lower
Inflammatory activation	higher	moderate	lower	lower
Field blood saver and cardiotomy reservoir	yes	no	no	no
ACT	> 480 s	< 200 s	< 200 s	< 200 s
Bleeding	severe	moderate	mild	mild
Cannulation	central or peripheral	peripheral	peripheral	peripheral
Runtime	< 6 h	< 6 h	weeks and back to ICU	weeks and back to ICU
Cost	lower	moderate	higher	higher
Cancer dissemination risk	yes	no	no	no

CPB cardiopulmonary bypass, m-CPB modified cardiopulmonary bypass, VV-ECMO veno-venous extracorporeal membrane oxygenation, VA-ECMO veno-arterial extracorporeal membrane oxygenation, ACT activated clotting time