Table 3.

Expected and observed cumulative doses and interaction index (γ) for the combinations of local anesthetics

Group	Expected short LA (mg/kg)	Expected long LA (mg/kg)	Observed short LA (mg/kg) median (IQR)	Observed long LA (mg/kg) median (IQR)	γ median (IQR)
LRa Lidocaine 10 mg/mL Ropivacaine 2.5 mg/mL	43.77	15.17	52.00 (45.15 – 57.13)	13.00 (11.29 – 14.28)	1.02 (0.89 – 1.12)
LRb Lidocaine 10 mg/mL Ropivacaine 1.25 mg/mL	65.66	7.58	64.70 (51.70 – 67.17)	8.09 (6.46 – 8.40)	1.01 (0.80 – 1.04)
LRc Lidocaine 5 mg/mL Ropivacaine 1.25 mg/mL	21.89	22.75	31.82 (31.17 – 35.19)	15.91 (15.58 – 17.60)	0.89 (0.87 – 0.98)
LLa Lidocaine 10 mg/mL Levobupivacaine 2.5 mg/mL	43.77	14.32	51.00 (47.23 – 53.32)	12.75 (11.81 – 13.33)	1.03 (0.95 – 1.08)
LLb Lidocaine 10 mg/mL Levobupivacaine 1.25 mg/mL	65.66	7.16	54.73 (47.55 – 58.38)	6.84 (5.94 – 7.30)	0.86 (0.75 – 0.92)
LLc Lidocaine 5 mg/mL Levobupivacaine 2.5 mg/mL	21.89	21.47	34.32 (32.32 – 40.32)	17.16 (16.16 – 20.16)	0.99 (0.93 – 1.17)
MRa Mepivacaine 10 mg/mL Ropivacaine 2.5 mg/mL	63.28	15.17	60.90 (59.12 – 69.43)	15.23 (14.78 – 17.36)	0.98 (0.95 – 1.12)
MRb Mepivacaine 10 mg/mL Ropivacaine 1.25 mg/mL	94.91	7.58	69.03 (64.52 – 84.78)	8.63 (8.06 – 10.60)	0.83 (0.78 – 1.02)
MRc Mepivacaine 5 mg/mL Ropivacaine 2.5 mg/mL	31.64	22.75	39.28 (38.16 – 43.38)	19.64 (19.08 – 21.69)	0.96 (0.93 – 1.06)
MLa Mepivacaine 10 mg/mL Levobupivacaine 2.5 mg/mL	63.28	14.32	58.93 (54.87 – 61.40)	14.73 (13.72 – 15.35)	0.98 (0.91 – 1.02)
MLb Mepivacaine 10 mg/mL Levobupivacaine 1.25 mg/mL	94.91	7.16	65.70 (62.05 – 76.68)	8.21 (7.76 – 9.59)	0.81 (0.76 – 0.94)
MLc Mepivacaine 5 mg/mL Levobupivacaine 2.5 mg/mL	31.64	21.47	37.87 (35.78 – 39.94)	18.93 (17.89 – 19.97)	0.96 (0.91 – 1.01)

LA local anesthesia, IQR interquartile range