Table 2.

Meta-analysis results of adverse events

Any grade					Grade ≥ 3
Adverse events	No of study	I2(%)	proportion (95%CI)	P	Adverse events	No of study	I2(%)	proportion (95%CI)	P
Any	6	95.6	0.98(0.90, 1.00)	< 0.0001	Any	6	91.7	0.76(0.52, 0.94)	< 0.0001
Anemia	8	84.8	0.61(0.30, 0.88)	< 0.0001	Anemia	8	95.9	0.09(0.01 0.22)	< 0.0001
Diarrhea	8	84.8	0.20(0.11, 0.31)	< 0.0001	Diarrhea	8	26.1	0.01(0.00, 0.02)	< 0.0001
Leukopenia	9	98.0	0.46(0.25, 0.68)	< 0.0001	Leukopenia	9	97.5	0.10(0.01, 0.25)	< 0.0001
Nausea	7	84.7	0.76(0.57, 0.88)	< 0.0001	Nausea	7	0	0.02(0.00 0.03)	< 0.0001
Rash	9	85.7	0.19(0.11, 0.31)	< 0.0001	Rash	9	68.3	0.01(0.00, 0.04)	0.0014
Thrombocytopenia	8	90.8	0.16(0.07, 0.34)	< 0.0001	Thrombocytopenia	8	92.0	0.04(0.00, 0.12)	< 0.0001