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ICEs defined in study protocols (n = 81)
| ICE | n (%) |
|---|---|
| Treatment non-adherence / no reason specified | 68 (84.0) |
| Treatment non-adherence / due to adverse event | 7 (8.6) |
| Treatment non-adherence / not due to an adverse event | 5 (6.2) |
| Use of rescue therapy | 29 (35.8) |
| Treatment switching | 3 (3.7) |
| Death | 2 (2.5) |
| Other terminal event | 1 (1.2) |
| Other ICE | 18 (22.2) |
ICE intercurrent event
