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. 2025 Aug 26;26:310. doi: 10.1186/s13063-025-08991-8

Table 6.

Strategy for handling of treatment non-adherence with no reason specified

ICE strategy n (%)
 Treatment policy 35/62 (56.5)
 Hypothetical 15/62 (24.2)
 Composite 10/62 (16.1)
 Principal stratum 0/62 (0.0)
 While-on-treatment 2/62 (3.2)
Hypothetical scenarioa
 Given 4/15 (26.7)
 Not given 11/15 (73.3)

ICE intercurrent event

aDid the authors state how the envisaged hypothetical scenario would occur, e.g., for treatment discontinuation due to adverse events did the authors envisage participants continuing treatment despite the adverse events, or something else?