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. 2025 Aug 26;26:310. doi: 10.1186/s13063-025-08991-8

Table 7.

Strategy for handling use of rescue medication (n = 81)

ICE strategy n (%)
 Treatment policy 8/24 (33.3)
 Hypothetical 5/24 (20.8)
 Composite 11/24 (45.8)
 Principal stratum 0/24 (0.0)
 While-on-treatment 0/24 (0.0)
Hypothetical scenarioa
 Given 0/5 (0.0)
 Not given 5/5 (100.0)

ICE intercurrent event

aDid the authors state how the envisaged hypothetical scenario would occur, e.g., for treatment discontinuation due to adverse events did the authors envisage participants continuing treatment despite the adverse events, or something else?