Table 4.

Anti-leishmanial activity and selectivity index of leptin and glucantime

Treatment types	IC50 on promastigotes	IC50 on amastigotes	CC50 on macrophages	Selective index
Glu (μg/ml)	239.34 ± 0.17	108.9 ± 0.09	749.18 ± 0.044	6.87
Leptin (ng/ml)	16.57 ± 0.3	7.81 ± 0.05	61.53 ± 0.079	7.88
Leptin + Glu	10.41 ± 0.47	2.47 ± 0.026	43.62 ± 0.2	17.66

IC50 half-maximum inhibitory concentration, CC50 concentration of cytotoxicity 50%. SI = selectivity index of a drug is the ratio of the toxic concentration to its effective bioactive concentration = CC50/IC50 ≥ 10, non-toxic