Table 4.
Effect of MoS2 NF on CBC profile of rats group in sub-acute and pregnant rats in developmental toxicity studies
| Parameters | Units | Sub-acute toxicity | Developmental toxicity | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Male | Female | ||||||||
| Control | MoS2NF | Control | MoS2NF | Control | MoS2 NF | ||||
| 3 mg/kg | 10 mg/kg | 3 mg/kg | 10 mg/kg | 10 mg/kg | |||||
| Hemoglobin | g/dL | 15.37 ± 0.51 | 14.16 ± 0.92 | 13.60 ± 0.81 | 10.96 ± 1.4 | 12.23 ± 0.77 | 14.56 ± 1.10 | 14.56 ± 1.10 | 13.40 ± 1.03 |
| RBCs | ×1012/L | 6.77 ± 0.26 | 7.3 ± 0.49 | 7.36 ± 0.42 | 4.67 ± 0.38 | 6.26 ± 0.31 | 7.5 ± 0.5** | 5.00 ± 0.89 | 6.43 ± 1.10 |
| WBCs | ×109/L | 9.07 ± 1.3 | 8.40 ± 1.09 | 10.6 ± 1.27 | 4.20 ± 1.3 | 6.5 ± 1.26 | 3.92 ± 0.97 | 807.3 ± 63.04 | 1109 ± 68.45* |
| Platelet count | ×109/L | 402.6 ± 9.1 | 850.6 ± 42.67 *** | 533.33 ± 28.6 * | 752.33 ± 7.2 | 656.3 ± 29.9 | 836.6 ± 37.8 | 4.66 ± 0.63 | 6.83 ± 1.04 |
| Neutrophils | % | 66.66 ± 4.4 | 7.33 ± 0.88^^^ | 10.33 ± 1.45^^^ | 29.27 ± 0.65 | 10.66 ± 1.2^^^ | 25.0 ± 1.15^ | 48.33 ± 3.38 | 20.33 ± 2.02^^ |
| Lymphocytes | % | 39.66 ± 2.6 | 90.0 ± 2.3*** | 85.33 ± 2.02*** | 64.0 ± 2.6 | 82.3 ± 4.8* | 70.0 ± 3.46 | 40.00 ± 2.64 | 74.33 ± 2.64 |
Data are represented as mean ± SEM, n = 5, *P < 0.05, **P < 0.01, ***P < 0.001 as compared with normal control. *indicates increase levels while ^indicate decreased levels