Table 7.

Effect of MoS₂ on liver, renal function tests and lipid profile in sub-acute toxicity studies at 3 mg/kg and 10 mg/kg dose levels

Male					Control group	Female
LFTs	Units	Control group	MoS2 NF			MoS2 NF
			3 mg/kg	10 mg/kg		3 mg/kg	10 mg/kg
ALT	U/L	39.33 ± 2.60	86.0 ± 3.4***	56.0 ± 3.2*	35.3 ± 1.76	88.0 ± 3.4***	58.33 ± 3.48**
ALP	U/L	113.6 ± 8.9	183.3 ± 5.54**	216.3 ± 10.4***	107.33 ± 2.9	203.0 ± 10.4**	414.0 ± 16.0***
AST	U/L	38.3 ± 2.3	147.3 ± 7.8***	106.3 ± 4.6***	31.33 ± 1.76	135.33 ± 4.91***	136.0 ± 5.68***
RFTs
Creatinine	mg/dL	0.53 ± 0.06	0.60 ± 0.05	0.68 ± 0.04	0.76 ± 0.03	0.61 ± 0.04	0.53 ± 0.03^^
Urea	mg/dL	48.0 ± 1.52	43.3 ± 2.60	53.33 ± 1.76	42.66 ± 1.45	56.0 ± 2.08**	51.0 ± 2.30*
Lipid Profile
Cholesterol	mg/dL	98.3 ± 2.3	116.0 ± 3.05**	90.6 ± 2.9	105.3 ± 1.7	93.6 ± 3.5 ^	72.3 ± 1.76^^^
Triglycerides	mg/dL	80.66 ± 2.96	94.6 ± 2.9*	97.0 ± 3.05 *	88.6 ± 2.02	114.3 ± 3.2 **	104.0 ± 3.60*
HDL	mg/dL	48.3 ± 1.45	50.0 ± 2.08	49.0 ± 1.73	45.6 ± 1.4	5.1.3 ± 1.76	53.3 ± 2.3*
LDL	mg/dL	48.6 ± 2.02	46.0 ± 2.8	49.6 ± 2.02	63.6 ± 2.02	28.6 ± 2.02^^^	81.0 ± 2.6**
VLDL	mg/dL	19.0 ± 1.15	17.3 ± 0.8	20.0 ± 1.15	24.0 ± 1.15	20.6 ± 0.8	23.6 ± 1.45

Data are expressed as mean ± SEM, n = 5, *p < 0.05, **p < 0.01, ***p < 0.001 as compared with normal control. *indicates increase levels while ^indicate decreased levels