Table 7.

Ablation study results of refinement model on HG001 and HG002

Train data	Test data	Training Feature	Suboptimal SA		Optimal SA
			F1 score	AUC-ROC	F1 score	AUC-ROC
HG001	HG002	all	0.949	0.905	0.946	0.909
		w/o AF	0.946	0.882	0.955	0.914
		w/o CF	0.944	0.894	0.939	0.890
		w/o AF + CF	0.921	0.819	0.932	0.822
HG002	HG001	all	0.934	0.861	0.948	0.889
		w/o AF	0.934	0.85	0.944	0.880
		w/o CF	0.929	0.852	0.949	0.894
		w/o AF + CF	0.909	0.807	0.930	0.833
Mixed 50%	Mixed 50%	all	0.946	0.894	*
		w/o AF	0.941	0.876
		w/o CF	0.94	0.883
		w/o AF + CF	0.915	0.812

*By considering data leakage, this experiment was not performed