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. 2025 Aug 26;25:885. doi: 10.1186/s12884-025-08031-y

Table 4.

Conditional logistic regression on risk factors of neonates acquiring early-onset sepsis

Unadjusted model Adjusted model
(Full model)
Adjusted model*
(Forward stepwise model)
OR 95% CI p value OR 95% CI p value OR 95% CI p value
Maternal factors
Maternal fever 2.96 1.35 to 6.47 0.007 1.76 0.71 to 4.35 0.224
Chorioamnionitis 17.19 6.33 to 46.67 < 0.001 8.74 2.97 to 25.71 < 0.001 8.99 3.07 to 26.33 < 0.001
Maternal genitourinary tract infections 2.55 1.79 to 3.64 < 0.001 1.85 1.22 to 2.81 0.004 1.85 1.22 to 2.80 0.004
Maternal group B streptococcus (GBS) colonization 1.13 0.83 to 1.52 0.443 1.15 0.85 to 1.57 0.375
Maternal pneumonia 16.89 6.77 to 42.12 < 0.001 16.75 6.57 to 42.69 < 0.001 17.35 6.85 to 43.90 < 0.001
Premature rupture of membranes (PROM) 1.61 1.28 to 2.04 < 0.001 1.69 1.33 to 2.15 < 0.001 1.69 1.32 to 2.15 < 0.001
Delivery by Cesarean section 1.64 1.46 to 1.83 < 0.001 1.47 1.29 to 1.67 < 0.001 1.45 1.28 to 1.64 < 0.001
Maternal systemic lupus erythematosus (SLE) 1.61 0.76 to 3.43 0.213 1.17 0.52 to 2.60 0.706
Maternal diabetes mellitus 1.86 1.46 to 2.36 < 0.001 1.97 1.53 to 2.53 < 0.001 1.95 1.52 to 2.51 < 0.001
Maternal antibiotics usage 1.55 1.37 to 1.75 < 0.001 1.32 1.16 to 1.50 < 0.001 1.33 1.17 to 1.52 < 0.001
Steroid (betamethasone or dexamethasone) usage 1.93 1.19 to 3.13 0.008 1.20 0.72 to 1.99 0.480
Neonatal factors
Gestational age (weeks) 0.86 0.82 to 0.91 < 0.001 1.02 0.96 to 1.08 0.558
Birth weight (per 100 g) 0.99 0.99 to 0.99 < 0.001 0.99 0.99 to 0.99 < 0.001 0.99 0.99 to 0.99 < 0.001
Birth injury 0.75 0.22 to 2.53 0.642 0.70 0.17 to 2.90 0.622
Meconium aspiration syndrome (MAS) 1.09 0.41 to 2.87 0.862 0.38 0.08 to 1.75 0.214

*The Hosmer-Lemeshow test was 0.72, and the area under the curve was 0.621