Table 4.
Conditional logistic regression on risk factors of neonates acquiring early-onset sepsis
| Unadjusted model | Adjusted model (Full model) |
Adjusted model* (Forward stepwise model) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | p value | OR | 95% CI | p value | OR | 95% CI | p value | |
| Maternal factors | |||||||||
| Maternal fever | 2.96 | 1.35 to 6.47 | 0.007 | 1.76 | 0.71 to 4.35 | 0.224 | |||
| Chorioamnionitis | 17.19 | 6.33 to 46.67 | < 0.001 | 8.74 | 2.97 to 25.71 | < 0.001 | 8.99 | 3.07 to 26.33 | < 0.001 |
| Maternal genitourinary tract infections | 2.55 | 1.79 to 3.64 | < 0.001 | 1.85 | 1.22 to 2.81 | 0.004 | 1.85 | 1.22 to 2.80 | 0.004 |
| Maternal group B streptococcus (GBS) colonization | 1.13 | 0.83 to 1.52 | 0.443 | 1.15 | 0.85 to 1.57 | 0.375 | |||
| Maternal pneumonia | 16.89 | 6.77 to 42.12 | < 0.001 | 16.75 | 6.57 to 42.69 | < 0.001 | 17.35 | 6.85 to 43.90 | < 0.001 |
| Premature rupture of membranes (PROM) | 1.61 | 1.28 to 2.04 | < 0.001 | 1.69 | 1.33 to 2.15 | < 0.001 | 1.69 | 1.32 to 2.15 | < 0.001 |
| Delivery by Cesarean section | 1.64 | 1.46 to 1.83 | < 0.001 | 1.47 | 1.29 to 1.67 | < 0.001 | 1.45 | 1.28 to 1.64 | < 0.001 |
| Maternal systemic lupus erythematosus (SLE) | 1.61 | 0.76 to 3.43 | 0.213 | 1.17 | 0.52 to 2.60 | 0.706 | |||
| Maternal diabetes mellitus | 1.86 | 1.46 to 2.36 | < 0.001 | 1.97 | 1.53 to 2.53 | < 0.001 | 1.95 | 1.52 to 2.51 | < 0.001 |
| Maternal antibiotics usage | 1.55 | 1.37 to 1.75 | < 0.001 | 1.32 | 1.16 to 1.50 | < 0.001 | 1.33 | 1.17 to 1.52 | < 0.001 |
| Steroid (betamethasone or dexamethasone) usage | 1.93 | 1.19 to 3.13 | 0.008 | 1.20 | 0.72 to 1.99 | 0.480 | |||
| Neonatal factors | |||||||||
| Gestational age (weeks) | 0.86 | 0.82 to 0.91 | < 0.001 | 1.02 | 0.96 to 1.08 | 0.558 | |||
| Birth weight (per 100 g) | 0.99 | 0.99 to 0.99 | < 0.001 | 0.99 | 0.99 to 0.99 | < 0.001 | 0.99 | 0.99 to 0.99 | < 0.001 |
| Birth injury | 0.75 | 0.22 to 2.53 | 0.642 | 0.70 | 0.17 to 2.90 | 0.622 | |||
| Meconium aspiration syndrome (MAS) | 1.09 | 0.41 to 2.87 | 0.862 | 0.38 | 0.08 to 1.75 | 0.214 | |||
*The Hosmer-Lemeshow test was 0.72, and the area under the curve was 0.621