Table 3.
Associations between CSVD burden score and motor parameters mediated by MoCA score
| Outcome variable | Effect | Unadjusted analysis | Adjusted analysis† | ||
|---|---|---|---|---|---|
| β/estimate (95% CI) | P value | β/estimate (95% CI) | P value | ||
| SPPB score | Total Effect (TE) | − 0.725 (− 1.106, − 0.344) | < 0.001 | − 0.685 (− 1.062, − 0.309) | < 0.001 |
| Natural Direct Effect (NDE) | − 0.456 (− 0.821, − 0.091) | 0.014 | − 0.454 (− 0.818, − 0.089) | 0.015 | |
| Natural Indirect Effect (NIE) | − 0.269 (− 0.475, − 0.063) | 0.010 | − 0.232 (− 0.423, − 0.041) | 0.017 | |
| Percentage Mediated (PM) | 37.083 (8.709, 65.457) | 0.010 | 33.835 (5.670, 61.999) | 0.019 | |
| Speed | Total Effect (TE) | − 0.047 (− 0.086, − 0.009) | 0.016 | − 0.042 (− 0.079, − 0.004) | 0.054 |
| Natural Direct Effect (NDE) | − 0.029 (− 0.068, 0.010) | 0.143 | − 0.029 (− 0.067, 0.010) | 0.146 | |
| Natural Indirect Effect (NIE) | − 0.018 (− 0.035, − 0.001) | 0.041 | − 0.013 (− 0.028, 0.002) | 0.082 | |
| Percentage Mediated (PM) | 38.042 (− 5.247, 81.332) | 0.085 | 31.798 (− 10.889, 74.486) | 0.144 | |
| Stride length | Total Effect (TE) | − 0.048 (− 0.082, − 0.014) | 0.006 | − 0.043 (− 0.076, − 0.010) | 0.011 |
| Natural Direct Effect (NDE) | − 0.030 (− 0.064, 0.004) | 0.085 | − 0.029 (− 0.063, 0.004) | 0.086 | |
| Natural Indirect Effect (NIE) | − 0.018 (− 0.034, − 0.002) | 0.028 | − 0.013 (− 0.027, 0.000) | 0.057 | |
| Percentage Mediated (PM) | 37.245 (− 0.336, 74.826) | 0.052 | 31.341 (− 5.518, 68.199) | 0.096 | |
| Stride time | Total Effect (TE) | 0.010 (− 0.016, 0.035) | 0.459 | 0.008 (− 0.017, 0.033) | 0.535 |
| Natural Direct Effect (NDE) | 0.004 (− 0.022, 0.031) | 0.777 | 0.004 (− 0.023, 0.030) | 0.787 | |
| Natural Indirect Effect (NIE) | 0.006 (− 0.004, 0.015) | 0.245 | 0.004 (− 0.005, 0.013) | 0.337 | |
| Percentage Mediated (PM) | 59.724 (− 123.35, 242.79) | 0.523 | 54.341 (− 146.460, 255.140) | 0.596 | |
| Hip ROM | Total Effect (TE) | − 7.556 (− 14.706, − 0.406) | 0.038 | − 7.301 (− 14.487, − 0.114) | 0.047 |
| Natural Direct Effect (NDE) | − 4.300 (− 11.592, 2.993) | 0.248 | − 4.310 (− 11.603, 2.983) | 0.247 | |
| Natural Indirect Effect (NIE) | − 3.256 (− 6.420, − 0.092) | 0.044 | − 2.991 (− 6.023, 0.041) | 0.053 | |
| Percentage Mediated (PM) | 43.094 (− 9.975, 96.164) | 0.112 | 40.968 (− 11.598, 93.534) | 0.127 | |
| Knee ROM | Total Effect (TE) | − 1.905 (− 3.221, − 0.590) | 0.005 | − 1.698 (− 2.968, − 0.428) | 0.009 |
| Natural Direct Effect (NDE) | − 1.039 (− 2.318, 0.239) | 0.111 | − 1.016 (− 2.270, 0.238) | 0.112 | |
| Natural Indirect Effect (NIE) | − 0.866 (− 1.549, − 0.183) | 0.013 | − 0.682 (− 1.280, − 0.084) | 0.025 | |
| Percentage Mediated (PM) | 45.454 (5.879, 85.028) | 0.024 | 40.167 (0.313, 80.021) | 0.048 | |
| Ankle ROM | Total Effect (TE) | − 4.842 (− 9.681, − 0.002) | 0.050 | − 4.689 (− 9.556, 0.177) | 0.059 |
| Natural Direct Effect (NDE) | − 3.738 (− 8.827, 1.352) | 0.150 | − 3.729 (− 8.818, 1.361) | 0.151 | |
| Natural Indirect Effect (NIE) | − 1.104 (− 2.947, 0.739) | 0.240 | − 0.960 (− 2.695, 0.774) | 0.278 | |
| Percentage Mediated (PM) | 22.801 (− 20.555, 66.157) | 0.303 | 20.482 (− 21.309, 62.274) | 0.337 | |
SPPB Short Physical Performance Battery; ROM range of motion; CI confidence interval
†: Adjusted for age