Table 3.
Association of skin autofluorescence with incident cancer in individuals without type 2 diabetes at baseline
| Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | HR (95%CI) | HR (95%CI) | ||||
| SAF (AU) | 2.33 (2.23–2.43) | *** | 1.14 (1.08–1.21) | *** | 1.11 (1.05–1.18) | *** |
| Age (yrs) | 1.05 (1.05–1.06) | *** | 1.06 (1.05–1.06) | *** | ||
| Female sex | 1.21 (1.16–1.26) | *** | 1.29 (1.23–1.37) | *** | ||
| BMI (kg/m2) | 0.97 (0.96–0.98) | *** | ||||
| Waist (cm) | 1.00 (1.00-1.01) | * | ||||
| Pack-years of smoking (n) # | 1.12 (1.07–1.16) | *** | ||||
| Alcohol intake (g/day) # | 1.07 (1.03–1.12) | ** | ||||
| Presence of metabolic syndrome | 1.06 (0.98–1.14) | |||||
Model 1 is a crude Cox proportional hazards model for examining the relationship (hazard ratio) between SAF and the occurrence of cancer; Model 2 adjusts for age and sex, and Model 3 adjusts for age, sex, BMI, waist circumference, pack- years of smoking, alcohol intake, and the presence of the metabolic syndrome
Model 1 & 2 n = 75,678, model 3 n = 70,075 due to missing measurements
# log-transformed; * p < 0.05, ** p < 0.01, *** p < 0.001
BMI, body mass index; SAF, skin autofluorescence