FIG. 4.

Cell growth curves of HEK293, HEK293/vector, and HEK293/SULT1C3 cells treated with tolvaptan (0.78–75 μM) for 24, 48, or 96 h (A). The results shown are the mean and standard deviation of 3 independent experiments. (B) The IC50 values obtained from the cell growth curves shown in (A) using GraphPad Prism 6.0. Values in the parenthesis are the 95% confidence intervals of the IC50. *: significantly (P < .05) different from HEK293 cells and HEK293/vector cells.