Table 1:

Studies that have elucidated indoor allergen removal

Study	Allergen	Methodology	Summary of results
Rabito et al.	Cockroach	Enrolment included 102 children-adolescents from 5–17 years of age with moderate to severe asthma in a 12-month randomized controlled trial. This study tested the use of insecticidal bait on cockroach counts and asthma morbidity.	Asthma morbidity was improved with this single intervention.
Chen et al.	House Dust Mite	Sixty-six dust mite sensitive children 3–12 years of age with asthma and allergic rhinitis were assigned an acaricidal bait intervention or placebo intervention.	Dust mite exposure was reduced and rhinitis symptoms improved in the Acaricidal bait group when compared to the placebo group.
Terreehorst et al.	House Dust Mite	279 allergic rhinitis patients were randomly assigned to receive impermeable or non-impermeable mattress/pillow/blanket covers.	Covers with mite-proof bedding reduced the level of exposure to mite allergens.
Murray et al.	House Dust Mite	434 mite-sensitized children (ages 3–17) with asthma were randomized to receive mite-impermeable or control bed encasings.	Mite-impermeable encasings reduced asthma exacerbations.
Maya-Manzano et al.	House Dust Mite, Cat, and Dog	Sampled indoor air (with and without air filtration) with a cascade impactor in homes.	Dust mite, cat and dog allergens were effectively removed with air filtration.
Green et al.	Dog	The effect of a HEPA air cleaner was investigated in nine homes with a dog.	HEPA air cleaners effectively reduced airborne Can f 1 in homes with dogs.
Francis et al.	Cat and Dog	A randomized, parallel-group study evaluating the air cleaners in living/bedrooms of thirty asthmatic cat and dog sensitized adults sharing a home with cats or dogs.	Asthma outcomes were improved with the placement of air cleaners.
Matsui et al.	Mouse	Randomized clinical trial of mouse-sensitized and exposed children and adolescents (aged 5–17 years) to receive professionally delivered integrated pest management intervention (IPM) plus pest management education versus pest management education alone	There was no significant difference in maximal symptom days at 12 months between the two groups.
Phipatanakul W	Mouse	Eighteen homes of sensitized children and mild persistent asthma were randomized into intervention homes (received an integrated pest management intervention) and control homes (no intervention). Dust was analyzed for major allergens following the interventions and compared with control homes	Mouse allergen levels were significantly reduced during a 5-month period using IPMs.
Phipatanakul W	Pest	Randomized clinical trial of 236 students with asthma who were randomized to IPM by school and HEPA filter purifiers by classroom	The use of a school-wide IPM program or classroom HEPA filter purifiers did not significantly reduce asthma symptom-days.
Morgan WJ	Cockroach and Dust mite	Randomized controlled trial of 937 children with atopic asthma (5 to 11 years) evaluating education and remediation for exposure to both allergens and environmental tobacco smoke.	An individualized, home-based, comprehensive environmental intervention decreased exposure to cockroach and dust-mite allergens and reduced asthma-associated morbidity.