Table 2.
Independent comparative histologic evaluation of all cases
No. | Group | Species | PPH | Infection | Tissue type | Tissue Layers Present | Inflammation score (0–3) | Inflammation type | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
M | D | TS | SV | CM | ||||||||
1 | C | R | No | No | U + P | X | X | X | X | X | 0 | n/a |
2 | C | R | No | No | P | X | X | X | X | 0 | n/a | |
3 | C | H | No | No | P | X | X | X | X | 0 | n/a | |
4 | RP | R | No | Yes | U + P | X | X | X | X | X | 2a | Neutrophilic |
5 | RP | R | No | Yes | U + P | X | X | X | Necrosis | 3a | Neutrophilic | |
6 | RP | R | Yes | Nob | U + P | X | X | X | X | X | 1a | Neutrophilic |
7 | RP | H | Yes | No | P | X | X | X | X | 0 | n/a | |
8 | RP | H | Yes | No | P | X | X | X | X | 0 | n/a | |
9 | RP | H | No | No | P | X | X | 0 | n/a | |||
10 | RP | H | No | No | P | X | X | X | X | 0 | n/a | |
11 | RP | H | Yes | No | P | X | X | X | X | 0 | n/a | |
12 | RP | H | No | No | P | X | X | X | 0 | n/a | ||
13 | RP | H | Yes | No | P | X | X | X | 0 | n/a | ||
14 | RP | H | No | No | P | X | X | X | 0 | n/a | ||
15 | RP | H | No | No | P | X | X | X | 0 | n/a | ||
16 | RP | H | Yes | No | P | X | X | X | X | 0 | n/a | |
17 | RP | H | Yes | Yes | P | X | X | X | X | 0 | n/a |
C, control; CM, chorionic membrane; D, decidua; H, human; M, myometrium P, placenta; R, rhesus; RP, retained placenta; SV, syncytial villi; TS, trophoblastic shell; U, uterus. Infection information was provided from clinical documentation either from a routine pathology report for human cases or a necropsy report for NHPs.
Cases with 2 samples each, highest inflammation score reported in above table: case 4 details (score of 2 for sample with M + D; score of 0 for sample with D+TS+SV+CM), case 5 details: (score of 3 for sample with M + D; score of 2 for sample with D+TS), case 6 details: (score of 0 and 1 for first and second samples, both samples with all layers present).
Case without clinical documentation of infection but inflammation seen on H&E.