Table 2.
Individual mouse data per group
| Group | Recipient estrus stage | Donor euthanasia: no. of days after vaginal plug | Days of disease | Individual take ratea (%) | Mean counts of confirmed lesionsb | Endometriosis incidencec (%) |
|---|---|---|---|---|---|---|
| 1: Laparoscopy with discrete endometrial biopsies | Estrus | 8.5 | 41 | 20 (2/10) | 2.7 | 100 (95% CI: 65, 100) |
| Estrus | 8.5 | 42 | 40 (4/10) | |||
| Estrus | 9.5 | 36 | 20 (2/10) | |||
| Estrus | 9.5 | 34 | 30 (3/10) | |||
| Estrus | 10.5 | 36 | 25 (2/8) | |||
| Estrus | 9.5 | 34 | 20 (2/10) | |||
| Estrus | 9.5 | 34 | 20 (2/10) | |||
| Proestrus | 8.5 | 35 | 10 (1/10) | |||
| Diestrus | 9.5 | 33 | 60 (6/10) | |||
| Metestrus | 9.5 | 34 | 30 (3/10) | |||
| 2: Laparotomy with discrete endometrial biopsies | Proestrus | 9.5 | 35 | 10 (1/10) | 1.1 | 80 (95% CI: 44, 96) |
| Estrus | 9.5 | 35 | 10 (1/10) | |||
| Proestrus | 9.5 | 36 | 10 (1/10) | |||
| Proestrus | 9.5 | 35 | 0 (0/10) | |||
| Proestrus | 9.5 | 34 | 20 (2/10) | |||
| Proestrus | 9.5 | 35 | 0 (0/10) | |||
| Estrus | 9.5 | 34 | 2 (2/10) | |||
| Estrus | 9.5 | 35 | 10 (1/10) | |||
| Estrus | 9.5 | 37 | 10 (1/10) | |||
| Estrus | 9.5 | 37 | 20 (2/10) | |||
| 5: Laparoscopy with discrete endometrial biopsies in menstruating recipients | Menstruating | 9.5 | 35 | 20 (2/10) | 2.6 | 100 (95% CI: 65, 100) |
| 35 | 40 (4/10) | |||||
| 35 | 20 (2/10) | |||||
| 44 | 30 (3/10) | |||||
| 36 | 30 (3/10) | |||||
| 20 (2/10) | ||||||
| 40 (4/10) | ||||||
| 20 (2/10) | ||||||
| 40 (4/10) | ||||||
| 10 (1/10) | ||||||
| Individual lesion countd | ||||||
| 3: Laparoscopy with endometrial slurry | Estrus | 8.5 | 36 | 1 | 0.2 | 20 (95% CI: 3.5, 56) |
| Estrus | 8.5 | 34 | 1 | |||
| Estrus | 8.5 | 33 | 0 | |||
| Estrus | 8.5 | 33 | 0 | |||
| Proestrus | 8.5 | 36 | 0 | |||
| Diestrus | 8.5 | 32 | 0 | |||
| Diestrus | 9.5 | 32 | 0 | |||
| Diestrus | 9.5 | 35 | 0 | |||
| Diestrus | 9.5 | 34 | 0 | |||
| Diestrus | 8.5 | 34 | 0 | |||
| 4: Laparotomy with endometrial slurry | Estrus | 8.5 | 34 | 1 | 0.1 | 10 (95% CI: 0.5, 46) |
| Estrus | 8.5 | 35 | 0 | |||
| Estrus | 8.5 | 38 | 0 | |||
| Estrus | 8.5 | 35 | 0 | |||
| Estrus | 9.5 | 34 | 0 | |||
| Estrus | 9.5 | 35 | 0 | |||
| Estrus | 9.5 | 33 | 0 | |||
| Proestrus | 8.5 | 33 | 0 | |||
| Diestrus | 8.5 | 33 | 0 | |||
| Diestrus | 8.5 | 33 | 0 | |||
| Average days of disease | 34.85 (SD = 0.05) |
a
Individual take rate = number confirmed lesions/number of implanted biopsies × 100, expressed as a percentage.
b
Mean counts of confirmed lesions per mouse: group 1 SD = 1.4, group 2 SD = 0.74, group 3 SD = 0.42, group 4 SD = 0.32, group 5 SD = 1.17.
c
Endometriosis incidence per group, expressed as percentage of animals (n = 10) per paradigm that had confirmed endometriosis lesions histologically.
d
Individual confirmed endometrial lesion counts for slurry implanted animals.