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. Author manuscript; available in PMC: 2026 Jan 15.
Published in final edited form as: Mol Psychiatry. 2025 Jan 15;30(6):2718–2728. doi: 10.1038/s41380-024-02881-2

Figure 4.

Figure 4.

Lipid profiling of the NAcSh. CBD upregulated several bioactive lipids including arachidonic acid, SEA, OEA, 2-LG, 2-OG, PGLy, and S-Alanine (A). However, only linoleic acid was significantly increased in the vehicle cue animals and reversed in CBD cue rats (A). Linoleic acid levels positively correlated with the composite anxiety score (B). Open circles represent animals in the neutral group, closed circles animals in the cue group. Vehicle and CBD rats are depicted by grey and orange markers, respectively. Partial correlation analyses were used to estimate lipid networks. In neutral animals (C), arachidonic acid positively correlated with linoleic acid (for which it is a precursor). In cue animals, this correlation was lost, but CBD strengthened relationships between multiple lipid species especially arachidonic acid and OEA. Asterisks indicate significant relationship p<0.05. L-acid, linoleic acid; A-acid, arachidonic acid; 2-LG, 2-linoleoylglycerol; 2-OG, 2-oleoylglycerol; SEA, N-Stearoylethanolamine; OEA, N-Oleoylethanolamine.