Table 1.
Pharmacokinetics of CBD and CBDA in dogs administrated with CBD isolate, CBDA isolate, CBDA FS, CBD/CBDA FS oil1.
| Treatment | Treatment effect p-value4 |
|||||
|---|---|---|---|---|---|---|
| Item | CBD isolate | CBDA isolate | CBDA FS |
CBD2 | CBDA3 | |
| CBD/CBDA FS | ||||||
| n | 8 | 8 | 8 | 8 | 8 | |
| Cmax5 (ng/mL) | 69.80 ± 35.44 | 235.51 ± 65.59 | 208.28 ± 66.05 | 64.66 ± 37.05 | 229.30 ± 145.51 | * |
| Tmax6 (h) | 2.75 ± 2.31 | 1.75 ± 2.58 | 0.94 ± 0.68 | 3.75 ± 2.71 | 1.81 ± 2.55 | * |
| T1/2 el7,11 (h) | 3.76 ± 1.22 | 6.19 ± 3.06 | 6.63 ± 2.69 | 4.5 ± 3.46 | 4.68 ± 1.97 | ns |
| AUC8 (ng-h/mL) | 420.61 ± 45.52 | 1255.70 ± 463.52 | 997.59 ± 366.4 | 354.45 ± 124.65 | 1240.97 ± 450.55 | * |
| MRT9,11 (h) | 5.73 ± 1.88 | NA12 | NA13 | 7.04 ± 4.77 | 7.35 ± 3.06 | ns |
| Css10,11 (ng/ml) | 42.83 ± 4.62 | NA12 | NA13 | 51.10 ± 14.92 | 108.90 ± 32.48 | * |
Values are means ± standard deviation.
Pharmacokinetics of CBD in the CBD/CBDA full spectrum treatment.
Pharmacokinetics of CBDA in the CBD/CBDA full spectrum treatment.
p-values for specific treatment comparisons are presented in Table 2.
Maximum serum concentration.
Time of maximum concentration.
Half-life of elimination.
Area under the serum concentration curve (0 to 12 hours).
Mean residence time.
Steady state serum concentration.
Three dogs are missing due to low concentrations.
For CBDA isolate treatment, values for MRT and Css were not available due to low concentrations.
For CBDA full spectrum treatment, values for MRT and Css were not available due to low concentrations.