Table 2.
p-value of specific treatment comparisons of the pharmacokinetics for dogs administrated with CBD isolate, CBDA isolate, CBDA FS, CBD/CBDA FS oil1.
| Item | CBD in CBD/CBDA FS1 vs CBD isolate |
CBDA in CBD/CBDA FS vs CBDA isolate |
CBDA FS vs CBDA isolate |
CBDA isolate vs CBD isolate |
CBDA in CBD/CBDA FS vs CBD in CBD/CBDA FS |
|---|---|---|---|---|---|
| n | 8 | 8 | 8 | 8 | 8 |
| Cmax2 (ng/mL) | p = 0.979 | p = 0.949 | p = 0.945 | p < 0.001 | p < 0.001 |
| Tmax3 (h) | p = 0.799 | p = 0.999 | p = 0.918 | p = 0.120 | p = 0.019 |
| T1/2 el4 (h) | p = 0.999 | p = 0.944 | p = 0.997 | p = 0.402 | p = 0.962 |
| AUC5 (ng-h/mL) | p = 0.627 | p = 1.000 | p = 0.635 | p < 0.001 | p < 0.001 |
| MRT6 (h) | p = 0.989 | NA8 | NA8 | NA8 | p = 0.940 |
| Css7 (ng/ml) | p = 0.972 | NA8 | NA8 | NA8 | p = 0.012 |
1
Values are calculated based on log transformed data.
2
Maximum concentration.
3
Time of maximum concentration.
4
Half-life of elimination. Three dogs were removed from the model due to insufficient concentration.
5
Area under the serum concentration curve (0 to 12 hours).
6
Mean residence time.
7
Steady state serum concentration.
8
Data not available.