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. 2025 Aug 26;29(16):e70806. doi: 10.1111/jcmm.70806

FIGURE 8.

FIGURE 8

CENPA and CKS1B are overexpressed in PCa and promotes PCa cell proliferation. (A, B) Representative pictures showing the different protein levels of CENPA and CKS1B in patients with PCa with different Gleason scores. (C) siRNAs inducing gene silencing, reducing CENPA mRNA and protein levels in PC3. (D) Western blot analysis shows successful knockdown of CENPA protein. (E, F) CENPA silencing clearly inhibits the colony formation and proliferation of PC3 cells. (G) siRNAs inducing gene silencing, reducing CKS1B mRNA and protein levels in PC3. (H) Western blot analysis shows successful knockdown of CKS1B protein. (I, J) CKS1B silencing clearly inhibits the colony formation and proliferation of PC3 cells. (K) EdU staining assay elucidated remarkably fewer EdU‐positive cells in shCENPA group compared with NC group. (L) EdU staining assay elucidated remarkably fewer EdU‐positive cells in shCKS1B group compared with NC group. *p < 0.05, **p < 0.01, ***p < 0.001.