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. 2025 Aug 26;9:e77108. doi: 10.2196/77108

Table 4. All-subset regression models evaluating combinations of multimodal, noninvasive inflammatory biomarkers for predicting serum C-reactive protein (CRP) levelsa.

Regression model Adjusted R2
Model 1 Serum CRP~ sa-CRPb 0.518
Model 2 Serum CRP~u-CRPc 0.608
Model 3 Serum CRP~u-CRP/u-Crd 0.513
Model 4e Serum CRP~saCRP+u-CRP 0.761
Model 5 Serum CRP~saCRP+u-CRP/u-Cr 0.747
Model 6 Serum CRP~uCRP+u-CRP/u-Cr 0.691
Model 7 Serum CRP~saCRP+uCRP+u-CRP/u-Cr 0.745
a

Each model includes noninvasive markers as predictors: sa-CRP, u-CRP, and u-CRP/u-Cr.

b

sa-CRP: saliva C-reactive protein.

c

u-CRP: urine C-reactive protein.

d

u-CRP/uCr: creatinine-normalized urine C-reactive protein.

e

Model 4, which includes both sa-CRP and u-CRP, demonstrated the highest explanatory power.