Table 3.

Multivariable cox regression analysis for risk of incident cardiovascular disease in all childhood cancer survivors

	Incident cardiovascular event
	HR	95% CI
Cardiopulmonary fitness
Increase of one MET at baseline	0.80	0.72, 0.90
Cardiovascular disease at baseline
Yes	2.08	1.31, 3.29
No	1.0	1.0
Obesity at baseline
Yes	0.73	0.44, 1.18
No	1.0	1.0
Impaired glucose metabolism at baseline
Yes	1.42	0.75, 2.69
No	1.0	1.0
Hypertension at baseline
Yes	0.72	0.43, 1.20
No	1.0	1.0
Anthracyclines
Yes	2.27	1.44, 3.56
No	1.0	1.0
Chest radiation
Yes	1.58	1.05, 2.39
No	1.0	1.0

Model additionally adjusted for sex, age at assessment, age at diagnosis, meeting 2018 CDC guidelines for physical activity, smoking

Note: 237 participants missing their MET at baseline due to acute injury (1), cardiovascular disease (112), uncontrolled diabetes (26), gastrointestinal disease (1), kidney disease (16), liver failure (2), musculoskeletal disease (40) paralysis (4) pulmonary disease (15), recent stroke (9), surgical restrictions (1)

MET = metabolic equivalent