Table 4:

Multivariable cox regression analysis for the association of increasing cardiopulmonary fitness by one MET and subsequent cardiovascular disease in survivors with lower cardiopulmonary fitness levels and survivors with higher cardiopulmonary fitness levels.

	Subsequent cardiovascular disease
	Low cardiopulmonary fitness group		Normal cardiopulmonary fitness group
	HR	95% CI	HR	95% CI
Cardiopulmonary fitness
Increase of one MET	0.78	0.65, 0.96	0.90	0.70, 1.15
Cardiovascular disease at baseline
Yes	2.4	1.41, 4.1	1.34	0.51, 3.60
No	1.0	1.0	1.0	1.0
Obesity at baseline
Yes	0.71	0.39, 1.31	0.99	0.39, 2.52
No	1.0	1.0	1.0	1.0
Impaired glucose metabolism at baseline
Yes	1.81	0.90, 3.65	0.62	0.08, 4.88
No	1.0	1.0	1.0	1.0
Hypertension at baseline
Yes	0.81	0.44, 1.48	0.46	0.15, 1.41
No	1.0	1.0	1.0	1.0
Anthracyclines
Yes	1.78	1.05, 3.02	4.23	1.53, 11.644
No	1.0	1.0	1.0	1.0
Chest radiation
Yes	1.25	0.76, 2.08	1.88	0.84, 4.19
No	1.0	1.0	1.0	1.0

Categories were made from the distribution of peak METs the survivors achieved on the CPET, separated by age and sex

Low/Below average (< 50%), above average/high (≥ 50%)

Additionally adjusted for age, age at diagnosis, meeting 2018 CDC physical activity guidelines, smoking and gender

237 survivors were missing their CPET and could not be classified as low or below average. The reasons included acute injury (1), cardiovascular (112), diabetes (26), gastrointestinal (1), kidney disease (16), liver failure (2) musculoskeletal impairment (40), neurological impairment (10), paralysis (4), pulmonary impairment (15), cerebrovascular impairment (9), recent surgery (1). MET = Metabolic equivalent; HR = hazard ratio; CI = confidence interval