Table 1. Structure of amidinopeptides and folded controls.
| ||||
|---|---|---|---|---|
| Peptide | Amidine | sequencea | ||
| Orientation | Strand | Turn | Strand | |
| YKL | RYVEV | pG | OKILQ | |
| 1-Tyr(NH)2 | ‘Out’ | RY(NH)VEV | pG | OKILQ |
| 2-Val(NH)3 | ‘In’ | RYV(NH)EV | pG | OKILQ |
| 3-Glu(NH)4 | ‘Out’ | RYVE(NH)V | pG | OKILQ |
| 4-Gly(NH)7 | ‘Out’ | RYVEV | pG(NH) | OKILQ |
| 5-Orn(NH)8 | ‘In’ | RYVEV | pG | O(NH)KILQ |
| 6-Ile(NH)10 | ‘In’ | RYVEV | pG | OKI(NH)LQ |
| 7 | RYVEV | PG | OKILQ | |
| 8b |
|
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All peptides except 8 are capped at the N-terminus with Ac and have a C-terminal amide (–CONH2).
Head-to-tail cyclic peptide.