Table 1.
Characteristic of Subjects Stratified by HUA
| Variables | Total (n=1261) | Normouricemia (n=961) | HUA (n=300) | P value |
|---|---|---|---|---|
| Male, n (%) | 711 (56.4) | 513 (53.4%) | 198 (66%) | <0.001 |
| Age (yr) | 59 (48,68) | 60 (50,68) | 55 (40.25,66) | <0.01 |
| Duration (yr) | 8 (2,15.5) | 9 (3,16) | 6 (1,14) | <0.05 |
| Height (cm) | 169 (162,174) | 168 (160,174) | 170 (165,176) | <0.01 |
| Weight (kg) | 73 (64,83) | 71 (62.75,80) | 80 (70,90) | <0.01 |
| BMI (kg/m2) | 25.66 (23.44,28.41) | 25.25 (23.12,27.82) | 27.26 (24.73,30.06) | <0.01 |
| Smoking, n (%) | 448 (35.5) | 331 (34.4%) | 117 (39%) | 0.15 |
| Drinking, n (%) | 400 (31.7) | 295 (30.7%) | 105 (35%) | 0.162 |
| Family History of diabetes mellitus | 409 (32.4) | 296 (30.8%) | 113 (37.7%) | <0.05 |
| SBP (mmHg) | 133 (123,145) | 132 (122,145) | 134 (124,146) | 0.184 |
| DBP (mmHg) | 81 (74,89) | 80 (74,88) | 82 (76,90) | <0.05 |
| Hypertension, n (%) | 688 (54.6) | 509 (53%) | 179 (59.7%) | <0.05 |
| Hyperlipidemia, n (%) | 932 (73.9) | 691 (71.9%) | 241 (80.3%) | <0.05 |
| Gout, n (%) | 39 (3.1) | 11 (1.1%) | 28 (9.3%) | <0.001 |
| Lipid-lowering drug (%) | 932 (73.9) | 691 (71.9%) | 241 (80.3%) | <0.004 |
| Scr (μmol/L) | 60 (50,71) | 58 (49,68) | 68 (57,82) | <0.01 |
| (eGFRml/min per 1.73 m2) | 103.95 (92.29,117.21) | 104.61 (94.25,116.2) | 101.41 (81.64,121.04) | <0.05 |
| SUA (μmol/L) | 324 (201,456) | 324 (201,456) | 324 (201,374) | 0.267 |
| FPG (mmol/L) | 7.5 (5.9,9.6) | 7.5 (6,9.6) | 7.2 (5.8,9.48) | 0.232 |
| TC (mmol/L) | 4.86 (4.15,5.555) | 4.81 (4.09,5.52) | 4.98 (4.23,5.77) | <0.05 |
| TG (mmol/L) | 1.76 (1.245,2.65) | 1.62 (1.17,2.41) | 2.24 (1.68,3.42) | <0.01 |
| HDL-C (mmol/L) | 1.02 (0.88,1.2) | 1.05 (0.91,1.24) | 0.95 (0.83,1.09) | <0.01 |
| LDL-C (mmol/L) | 2.97 (2.41,3.59) | 2.97 (2.41,3.57) | 2.99 (2.44,3.68) | 0.359 |
| ALT, U/L | 21 (15,33) | 20 (14,29) | 24 (17,49.5) | <0.01 |
| AST, U/L | 18 (15,24) | 17 (14,22) | 20 (16,31) | <0.01 |
| GGT, U/L | 25 (17,39) | 24 (17,35) | 35 (22,60) | <0.01 |
| HbA1c, (%) | 8.3 (7,10.1) | 8.4 (7.1,10.1) | 8.1 (6.8,10) | 0.127 |
| WBC count (109/L) | 6.19 (5.21,7.33) | 6.12 (5.17,7.29) | 6.44 (5.33,7.53) | <0.05 |
| Monocyte count (109/L) | 0.48 (0.4,0.58) | 0.47 (0.39,0.57) | 0.5 (0.42,0.61) | <0.05 |
| Lymphocyte count (109/L) | 1.94 (1.57,2.37) | 1.93 (1.56,2.36) | 1.96 (1.6,2.38) | 0.435 |
| Monocyte count (109/L) | 3.4 (2.8,4.36) | 3.44 (2.8,4.28) | 3.56 (2.84,4.55) | 0.127 |
| MHR | 0.47 (0.36,0.61) | 0.45 (0.35,0.58) | 0.52 (0.41,0.68) | <0.01 |
Notes: Data are presented as number (percentage) for categorical variables and as median (with 25th and 75th percentiles) for continuous variables. Comparisons for category variables between groups were tested by χ2 test and comparisons of continuous variables between groups were tested by Mann–Whitney test.
Abbreviations: HUA, hyperuricemia; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; Scr, serum creatinine; SUA, serum uric acid; FPG, fasting plasma glucose; eGFR, estimated glomerular filtration rate; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; AlT, alanine transaminase; AST, aspartate aminotransferase; GGT, γ-Glutamyl Transpeptidase; HbA1c, Hemoglobin A1c; WBC, white blood cell; MHR, Monocyte to high-density lipoprotein ratio; NHR, neutrophil to high-density lipoprotein ratio.