Figure 12.

Representative fittings of the MS (blue), FK (green), BOCF (red) and BBOCF (purple) models to experimental data recorded from three different species, including human hearts with and without characteristics of Brugada syndrome. Note that for the last case (human data with Brugada phenotype), only BOCF and BBOCF model fits are shown. All cases use 1024 particles and 32 iterations with no pre-recording stimuli except for the last case, which uses 16 384 particles and 70 iterations, with the upper bounds for ${\tau }_{o1}$ and ${\tau }_{o2}$ increased to 1000 and 200, respectively, for both models to accommodate the slow recovery time. The normalization constant was set to 1 for the BOCF model for the human data with Brugada phenotype, and to 1.05 and 1.35 for the BBOCF model for the normal and Brugada human cases, respectively.