Table 5.
Mitochondrial transplantation effect on wound healing and aging.
| Author/Year | Model/Disease | Mitochondria source | Transfer parameters | Clinical & biological evidences | Mitochondrial mechanisms modulation |
|---|---|---|---|---|---|
|
| |||||
| Arroum 2024 [110] | C57BL/6J mice Aging and muscular function |
Hind limbs Mice Allogenic |
Dose: 109 mito Administration: IM Sites: 3 |
↑ maximal speed and distance | ↑ ATP level ↑ COX activity Plantaris: ↑parkin, TFAM, BNIP3, Drp1 Soleus: ↑parkin, DRP1, no effect TFAM BNIP3 Femoris: No effect |
| Arroum 2024 [111] | Rat Aging and muscular function |
Femoris Rat Allogenic |
Dose: 109 mito Administration: IM Sites: 3 |
No effect on speed and distance | ↑ ATP level ↑ COX activity Plantaris and soleus: ↑ fusion (OPA1), ↑ mitochondrial homeostasis (Parkin, TFAM) |
| Li 2024 [112] | Kunming mice Burn injury |
Liver Mice Allogenic |
Dose: 10 μg/g Administration: SC Site: not specified |
↑ healing regeneration, ↓ scarring ↓ apoptosis ↓ inflammation (TNFα, IL1β, IL6) ↑ IL10 |
Not investigated |
| Raz 2024 [113] | C57BL/6 mice Corneal wound healing |
Liver Mice Allogenic |
Dose: 25 μL mito preparation (fresh or fractioned) Administration: drop Site: eyes |
↑ re-epithelialization and better cyto-architecture ↓ cellular infiltration Only the fresh ↓ wound area |
↓ ATP level |
| Kshersagar 2023 [114] | Wistar rat Endometrium Injury |
Placenta Human Xenogeneic |
Dose: from 106 cells Administration: injection Site: intrauterine |
↑ regeneration ↑ endometrial protein junction |
↑ OXPHOS (activity CI, CII, CIII, CIV, CytB5, CytP450, NADPH-CytC red, NADH-CytC red) |
| Wu 2022 [115] | RCS/Kyo rat Retinal degeneration |
Liver Rat Allogenic |
Dose: 50–100 μg mito proteins Administration: injection Site: intra-retinal |
Restore retinal layer thickness ↑ number of cells (only 100 μg) Anti-degeneration activity |
Not investigated |
| Wu 2020 [116] | C57B/6 mice Hair aging |
Liver Mice Allogenic |
Dose: 200 μg mito proteins Administration: SC Site: not specified |
↑ hair length, number of hair follicles No effect on derma thickness ↑ collagen |
↑ ATP synthase ↑ mito quantity (mtDNA) |
ATP: adenosine tri-phosphate, BNIP3: Bcl-2/adenovirus E1B-interacting protein 3, COX: cytochrome C oxidase, DRP1: dynamin-related protein 1, IL: interleukin, IM: intra-muscular, mito: mitochondria, OPA1: optic atrophy 1, SC: subcutaneous, TFAM: mitochondrial transcription factor A, TNFα: tumor necrosis factor α, ↑: increase/ improve, ↓: decrease.