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. 2025 Aug 27;23:965. doi: 10.1186/s12967-025-06957-7

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — Caterpillar plot of Geometric Mean Ratios (GMR) between the first cycle (T1) and baseline in Best Overall Response (BOR) (A, left) and Progression Free Survival (PFS) (B, right) for sPD-L1 (also known as B7-H1), sLAG-3, sTIM-3, sCTLA-4, and sIFN-γ levels, adjusted for sex, age, stage, LDH, and ECOG PS. Four patients did not have plasma/serum available for the T1 evaluation