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. 2025 Aug 14;15(8):865. doi: 10.3390/brainsci15080865

Figure 1.

Figure 1

Growth in Huntington’s disease research publications over time. Number of publications related to Huntington’s disease indexed in PubMed from the initial clinical description in 1872 to 10 March 2025. A marked increase in publication volume is observed beginning in 1993, coinciding with the discovery of the genetic cause of HD—the CAG trinucleotide repeat expansion in the HTT gene—highlighting the pivotal impact of this breakthrough on research activity in the field [11].