| TIGR | Tandem Interspersed Guide RNA in TIGR-TAS system |
| Tas | TIGR-associated (proteins) in TIGR-Tas system |
| PAM | Protospacer Adjacent Motif (3′ NGG in Cas9 and 5′ TTT in Cas12) |
| CRISPR | Clustered regularly interspaced palindromic repeats |
| Cas | CRISPER associated (proteins) |
| tracrRNA | trans-activating CRISPR RNA |
| crRNA | CRISPR RNA |
| crRNA array | An array of multiple crRNAs that can target multiple sequences |
| sgRNA | Single-guide RNA; Engineered tracerRNA::crRNA fusion RNA; designed to target site preceding PAM in CRISPR-Cas system |
| tigRNA | Dual spacer guide RNA in TIGR-Tas system; A and B spacers target opposite DNA strands on the target; no PAM is required |
| tigRNA array | An array of multiple tigRNAs that can target multiple sequences |
| cOA | cyclic oligoadenylates; cofactors in Cas10 system |
| snoRNA | Short nucleolar RNA |
| ssDNA | Single-stranded DNA |
| ssRNA | Single-stranded RNA |
| Nop | Nucleolar protein |
| nCas9 | Nickase Cas9 |
| dCas9 | Catalytically dead Cas9 |
| RuvC | Resistant to Ultraviolet C nuclease domain |
| ADAR | Adenine deaminase |
| AAV | Adeno-associated virus |
| LNP | Lipid nanoparticle |
| CASCADE | CRISPR associated complex for antiviral defense |
| SF2 | Superfamily 2 helicase |
| TAD | Topologically associated domain in chromatin |
| CARF | CRISPR-associated Rossman fold |
| DETECTR | DNA endogenous-targeted CRISPR trans reporter |
| SHERLOCK | Specific high-sensitivity reporter unlocking |