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Brain concentrations of 2-PMPA following oral administration of cycloSal-based prodrugs 18a (A), 18b (B), 18c (C), and 21 (D). The prodrugs were orally administered at a dose equivalent to 10 mg/kg of 2-PMPA in mice. Data (nmol/g) expressed as a mean ± standard error (SEM) (n = 3).
