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. 2025 Aug 18;18(8):1215. doi: 10.3390/ph18081215
TAT Targeted alpha therapy
mCRPC metastatic castration-resistant prostate cancer
[225Ac]Ac-PSMA actinium-225-labelled prostate-specific membrane antigen
LET linear energy transfer
RLT radioligand therapy
Lu-177 lutetium-177
PSA prostate-specific antigen
ADT androgen deprivation therapy
PFS progression-free survival
RBE relative biological effectiveness
ECOG Eastern Cooperative Oncology Group
PCWG3 Prostate Cancer Clinical Trials Working Group 3
mHSPC hormone-sensitive metastatic prostate cancer
TV tumour volume
TL-PSMA Total lesion PSMA
TLG total lesion glycolysis
OS overall survival
Th-229 Thorium-229
RCTs Randomised Controlled Trials
t-MDS therapy-related myelodysplastic syndromes
EMA European Medicines Agency
FDA Food and Drug Administration
IAEA International Atomic Energy Agency
PARP poly (ADP-ribose) polymerase