Table 3.

ADME properties of the newly designed substituted indole derivatives (3a−j) with phenylsulfonylhydrazone fragment (–C=N–NH–SO₂–Ar) and 1,2-bis-indole hydrazine derivative (4): water solubility; GI absorption—gastrointestinal absorption; oral BA—oral bioavailability; BA score—bioavailability score; BBB permeability—blood–brain barrier permeability; CYP inhibition—inhibition of CYP enzymes; P-gp substrate—substrate of P-gp; drug likeness; synthetic access—synthetic accessibility.

ID	Water Solubility	GI Absorption	Oral BA	BA Score	BBB Permeability	CYP Inhibition	P-gp Substrate	Drug Likeness	Synthetic Access
3a	moderate	high	INSATU	0.55	no	2/5	no	yes	2.78
3b	moderate	high	INSATU	0.55	no	3/5	no	yes	3.07
3c	moderate	high	INSATU	0.55	no	4/5	no	yes	2.67
3d	poor	high	INSATU	0.55	no	4/5	no	yes	2.96
3e	moderate	high	INSATU	0.55	no	4/5	no	yes	2.67
3f	moderate	high	INSATU	0.55	no	4/5	no	yes	2.57
3g	moderate	high	INSATU	0.55	no	4/5	no	yes	2.65
3h	poor	high	INSATU	0.55	no	4/5	no	yes	2.95
3i	moderate	high	INSATU	0.55	no	4/5	no	yes	2.84
3j	moderate	high	INSATU	0.55	no	4/5	no	yes	2.84
4	poor	high	INSATU	0.55	yes	4/5	no	yes	2.40