ABC	ATP-binding cassette
ADCC	Antibody-dependent cell-mediated cytotoxicity
ADC	Antibody-drug conjugate
ADMET	Absorption, Distribution, Metabolism, Excretion, and Toxicity
AML	Acute myeloid leukemia
AOC	Antibody oligonucleotide conjugate
cBu	Cyclobutane-1,1-dicarboxamide
CDR	Complementarity-determining region
CEA	Carcinoembryonic antigen
CH	Heavy chain constant domain
CL	Light chain constant domain
CPP-scFv	Cell-penetrating peptide single-chain variable fragment
DAR	Drug-Antibody ratio
DM1	Mertansine
DXd	Deruxtecan
ECM	Extracellular matrix
EGFR	Epidermal growth factor receptor
Fab	Antigen-binding fragment
Fc	Crystallizable fragment
FcRn	Neonatal Fc receptor
Fv	Variable fragment of antibody
GCC	Guanylyl cyclase C
GSH	Glutathione
HCs	Heavy chains
HER2	Human Epidermal Growth Factor Receptor 2
H3-OPT	CDR-H3 optimization toolkit
HR	Homologous recombination
IC50	Half-maximal inhibitory concentration
IgG	Immunoglobulin G
LC	Light chain
Lys-MCC-DM1	Lysine-linked maytansinoid metabolite
mAb	Monoclonal antibody
MDR1	Multidrug resistance protein 1
MD	Molecular dynamics
MMAE	Monomethyl auristatin E
MSA	Multiple Sequence Alignment
NAMPT	Nicotinamide phosphoribosyltransferase
NHEJ	Non-homologous end joining
PABC	Para-aminobenzyl carbamate
PBD	Pyrrolobenzodiazepine
PEG	Polyethylene glycol
pLDDT	Predicted Local Distance Difference Test
PROTAC	Proteolysis Targeting Chimera
RAbD	RosettaAntibodyDesign
scFv	Single-chain variable fragment
SMCC	Succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate
STING	Stimulator of Interferon Genes
TAP	Therapeutic Antibody Profiler
T-DM1	Trastuzumab emtansine
TME	Tumor microenvironment
VH	Variable heavy chain domain
VL	Variable light chain domain