Skip to main content
. 2025 Aug 2;13(8):660. doi: 10.3390/toxics13080660
ACD Allergic contact dermatitis
ACGIH American Conference of Governmental Industrial Hygienists
AFE Adjustment factor for exposure considerations
AFH Adjustment factor for translation to human effects
AFIV Adjustment factor for interindividual variability
AOP Adverse outcome pathway
ARE Antioxidant response element
CASRN Chemical Abstract Service Registry Number
CD54 Cluster of differentiation 54
CD86 Cluster of differentiation 86
cm2 Square centimeters
CV75 75% cell viability
DPRA Direct Peptide Reactivity Assay
EC1.5 Concentration at 1.5-fold luciferase induction in KeratinoSens™
EC150 Concentration at 150% relative fluorescence intensity in human cell line activation test
EC200 Concentration at 200% relative fluorescence intensity in human cell line activation test
EC3 Three-fold effective concentration in local lymph node assay
EC3.0 Concentration at 3.0-fold luciferase induction in KeratinoSens™
EESOH-MIS Enterprise Environmental, Safety, and Occupational Health Management Information System
FITC fluorescein isothiocyanate
GHS Globally Harmonized System
GPMT Guinea pig maximization test
HaCaT Transfected immortalized human keratinocytes
h-CLAT Human cell line activation test
IC30 Concentration resulting in 30% reduction in cell viability in KeratinoSens™
IC50 Concentration resulting in 50% reduction in cell viability in KeratinoSens™
Imax Maximum fold luciferase induction in KeratinoSens™
k-DPRA Kinetic direct peptide reactivity assay
Keap1 Kelch-like ECH-associated protein 1
kmax Maximal rate of depletion in the kinetic direct peptide reactivity assay
LLNA Local lymph node assay
mg/100 cm2 Milligrams per 100 square centimeters
mL Milliliters
mM Millimolar
MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide
NAM New approach methodology
NESIL No expected sensitization induction level
NIOSH National Institute for Occupational Safety and Health
Nrf2 Nuclear factor-erythroid 2-related factor 2
OECD Organisation for Economic Co-operation and Development
OSHA Occupational Safety and Health Administration
PCSG Preliminary candidate surface guideline
pEC3 Preliminary three-fold effective concentration
PI propidium iodide
POD Point of departure
QSAR Quantitative structure-activity relationship
RFI Relative fluorescence intensity
USAF United States Air Force
VP Vapor pressure
w/v % Percent weight by volume
WoE Weight of evidence
µg/100 cm2 Micrograms per 100 square centimeters
µg/mL Micrograms per milliliter
µM Micromolar