Table 4. Change in SBP and DBP from baseline to follow-up by comorbidities .
Supplementary Table 1
Comb. 1: Amlodipine+Telmisartan, Comb. 2: Amlodipine+Atenolol, Comb. 3: Amlodipine+Bisoprolol, Comb. 4: Amlodipine+Metoprolol, Comb. 5: Amlodipine+Chlorthalidone+Telmisartan,Comb. 6: Amlodipine+Hydrochlorothiazide+Telmisartan, Comb. 7: Amlodipine+hydrochlorothiazide+Olmesartan.
SBP: systolic blood pressure, DBP: diastolic blood pressure, DM: diabetes mellitus, CAD: coronary artery disease, CKD: chronic kidney disease.
| Comorbidity | Visit | Statistics (N=10,194) | Amlodipine | Comb. 1 | Comb. 2 | Comb. 3 | Comb. 4 | Comb. 5 | Comb. 6 | Comb. 7 |
| Dyslipidemia | Visit 1 SBP | n | 878 | 1051 | 160 | 285 | 550 | 166 | 572 | 179 |
| Mean(SD) | 158.4(17.3) | 159.8(16.5) | 158.9(18.8) | 160.8(18.3) | 159.7(17.2) | 162.3(16.2) | 162.6(16.1) | 166.3(17.4) | ||
| Median | 160.0 | 160.0 | 160.0 | 160.0 | 160.0 | 160.0 | 160.0 | 165.0 | ||
| Min, Max | 122,200 | 121,200 | 125,200 | 124,200 | 121,200 | 121,200 | 121,200 | 121,200 | ||
| Visit 2 SBP | Mean(SD) | 140.7(15.8) | 138.3(15.9) | 139.0(17.8) | 139.0(16.9) | 140.4(17.0) | 139.6(16.7) | 139.3(17.0) | 142.8(17.5) | |
| Median | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | ||
| Min, Max | 100,194 | 70,200 | 100,180 | 101,200 | 90,200 | 93,190 | 94,200 | 108,200 | ||
| Change from Baseline (SBP) | Mean(SD) | -17.8(19.6) | -21.6(18.5) | -19.9(21.4) | -21.8(19.3) | -19.3(20.6) | -22.7(21.5) | -23.3(19.4) | -23.5(21.0) | |
| Median | -18.0 | -20.0 | -20.0 | -20.0 | -20.0 | -23.0 | -20.0 | -20.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| Dyslipidemia | Visit 1 DBP | n | 878 | 1051 | 160 | 285 | 550 | 166 | 572 | 179 |
| Mean(SD) | 93.9(7.7) | 94.8(8.4) | 94.8(8.4) | 94.9(8.0) | 94.3(7.9) | 94.9(8.2) | 95.6(8.9) | 97.4(9.0) | ||
| Median | 90.0 | 90.0 | 90.0 | 90.0 | 90.0 | 90.0 | 93.0 | 98.0 | ||
| Min, Max | 81,130 | 81,150 | 81,128 | 81,120 | 81,140 | 81,130 | 81,150 | 81,120 | ||
| Visit 2 DBP | Mean(SD) | 84.3(8.8) | 83.3(8.9) | 83.8(9.1) | 83.3(9.4) | 84.4(8.9) | 83.4(8.8) | 83.6(9.1) | 85.1(9.7) | |
| Median | 82.5 | 80.0 | 80.0 | 80.0 | 83.5 | 80.0 | 80.0 | 81.0 | ||
| Min, Max | 60,140 | 60,140 | 60,106 | 60,120 | 60,140 | 62,120 | 60,130 | 60,120 | ||
| Change from Baseline (DBP) | Mean(SD) | -9.6(10.3) | -11.4(10.3) | -11.0(11.2) | -11.7(10.3) | -9.9(10.3) | -11.5(10.2) | -12.0(10.4) | -12.3(10.9) | |
| Median | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| DM | Visit 1 SBP | n | 816 | 1306 | 199 | 222 | 472 | 183 | 691 | 197 |
| Mean(SD) | 159.6(17.6) | 160.5(16.6) | 159.7(18.5) | 162.8(17.8) | 161.2(17.4) | 162.3(16.8) | 162.9(17.3) | 167.3(17.6) | ||
| Median | 160.0 | 160.0 | 160.0 | 160.0 | 160.0 | 160.0 | 160.0 | 170.0 | ||
| Min, Max | 122,200 | 121,200 | 122,200 | 124,200 | 121,200 | 126,200 | 121,200 | 121,200 | ||
| Visit 2 SBP | Mean(SD) | 141.5(17.2) | 140.5(16.8) | 141.4(16.0) | 140.7(17.6) | 142.6(17.1) | 139.3(15.7) | 140.7(17.0) | 142.6(18.2) | |
| Median | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | ||
| Min, Max | 94,200 | 70,200 | 100,184 | 101,200 | 90,200 | 107,180 | 96,200 | 100,200 | ||
| Change from Baseline (SBP) | Mean(SD) | -18.1(20.0) | -20.0(19.2) | -18.4(20.5) | -22.1(19.4) | -18.6(20.9) | -23.0(21.1) | -22.1(19.8) | -24.6(20.1) | |
| Median | -20.0 | -20.0 | -20.0 | -20.0 | -20.0 | -20.0 | -20.0 | -24.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| DM | Visit 1 DBP | Mean(SD) | 93.8(7.9) | 94.9(7.9) | 94.0(8.2) | 94.3(6.9) | 94.4(8.2) | 94.9(7.7) | 95.2(8.4) | 96.9(8.3) |
| Median | 90.0 | 92.0 | 90.0 | 90.0 | 90.0 | 90.0 | 92.0 | 98.0 | ||
| Min, Max | 81,137 | 81,150 | 81,128 | 82,120 | 81,140 | 82,120 | 81,138 | 81,120 | ||
| Visit 2 DBP | Mean(SD) | 84.3(8.8) | 83.9(8.7) | 83.4(9.1) | 83.2(9.5) | 84.7(9.2) | 82.9(8.7) | 84.2(8.9) | 85.4(9.1) | |
| Median | 83.0 | 80.0 | 80.0 | 80.0 | 84.0 | 80.0 | 82.0 | 84.0 | ||
| Min, Max | 60,116 | 60,140 | 60,110 | 60,115 | 60,130 | 60,120 | 60,122 | 60,116 | ||
| Change from Baseline (DBP) | n | 816 | 1306 | 199 | 222 | 472 | 183 | 691 | 197 | |
| Mean(SD) | -9.4(10.1) | -11.0(10.0) | -10.6(10.5) | -11.1(10.2) | -9.6(10.5) | -12.0(9.1) | -11.1(10.6) | -11.5(10.9) | ||
| Median | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| CAD | Visit 1 SBP | n | 185 | 165 | 39 | 68 | 104 | 25 | 87 | 30 |
| Mean(SD) | 161.3(17.9) | 162.4(16.2) | 160.8(21.6) | 163.4(19.1) | 163.0(15.2) | 164.9(10.2) | 164.7(15.8) | 168.7(19.0) | ||
| Median | 160.0 | 160.0 | 160.0 | 161.0 | 160.0 | 170.0 | 165.0 | 170.0 | ||
| Min, Max | 122,200 | 126,200 | 126,200 | 130,200 | 128,200 | 147,180 | 126,200 | 126,200 | ||
| Visit 2 SBP | Mean(SD) | 142.5(17.1) | 139.6(15.7) | 138.4(20.5) | 139.9(17.3) | 141.1(17.8) | 139.6(16.3) | 139.5(17.2) | 145.9(15.3) | |
| Median | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 141.5 | ||
| Min, Max | 94,194 | 110,190 | 100,180 | 90,180 | 100,200 | 113,180 | 96,190 | 120,190 | ||
| Change from Baseline (SBP) | Mean(SD) | -18.8(21.7) | -22.8(19.9) | -22.4(26.2) | -23.5(21.0) | -21.9(20.7) | -25.3(17.8) | -25.2(21.6) | -22.8(23.8) | |
| Median | -18.0 | -20.0 | -20.0 | -22.5 | -20.0 | -20.0 | -24.0 | -20.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| CAD | Visit 1 DBP | n | 185 | 165 | 39 | 68 | 104 | 25 | 87 | 30 |
| Mean(SD) | 94.9(8.3) | 95.1(8.2) | 97.0(10.7) | 95.5(7.9) | 94.3(7.3) | 95.0(9.0) | 94.8(7.9) | 97.1(9.6) | ||
| Median | 90.0 | 91.0 | 94.0 | 92.5 | 90.0 | 90.0 | 92.0 | 98.0 | ||
| Min, Max | 81,120 | 82,135 | 82,130 | 83,120 | 81,120 | 82,120 | 82,120 | 83,120 | ||
| Visit 2 DBP | Mean(SD) | 84.9(9.6) | 83.0(7.7) | 84.1(8.4) | 84.0(9.9) | 82.9(8.9) | 82.7(9.6) | 83.1(8.7) | 86.8(12.1) | |
| Median | 83.0 | 80.0 | 81.0 | 80.5 | 80.0 | 80.0 | 80.0 | 86.5 | ||
| Min, Max | 60,140 | 68,103 | 60,104 | 65,115 | 68,130 | 62,110 | 60,110 | 69,120 | ||
| Change from Baseline (DBP) | Mean(SD) | -10.1(10.9) | -12.1(9.7) | -12.9(11.1) | -11.4(10.7) | -11.3(10.0) | -12.3(9.5) | -11.8(10.3) | -10.2(10.8) | |
| Median | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| CKD | Visit 1 SBP | n | 243 | 65 | 27 | 34 | 98 | 8 | 14 | 7 |
| Mean(SD) | 165.2(18.3) | 162.9(16.8) | 161.3(21.7) | 161.8(18.0) | 165.0(18.7) | 157.6(10.5) | 164.5(18.9) | 169.0(15.5) | ||
| Median | 166.0 | 160.0 | 160.0 | 160.0 | 161.5 | 157.5 | 160.0 | 166.0 | ||
| Min, Max | 122,200 | 130,200 | 125,194 | 135,200 | 128,200 | 140,178 | 140,200 | 150,197 | ||
| Visit 2 SBP | Mean(SD) | 145.0(17.7) | 142.8(16.9) | 140.1(20.2) | 142.7(20.0) | 147.9(21.5) | 134.0(29.7) | 146.7(14.2) | 139.1(22.9) | |
| Median | 140.0 | 140.0 | 140.0 | 140.0 | 146.5 | 127.5 | 140.0 | 143.0 | ||
| Min, Max | 100,200 | 100,180 | 100,180 | 120,200 | 90,200 | 94,180 | 120,170 | 110,170 | ||
| Change from Baseline (SBP) | Mean(SD) | -20.2(22.1) | -20.1(21.5) | -21.1(21.9) | -19.1(18.8) | -17.1(24.7) | -23.6(34.9) | -17.8(22.9) | -29.9(22.0) | |
| Median | -20.0 | -19.0 | -20.0 | -16.5 | -19.0 | -35.0 | -19.5 | -37.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.0972 | 0.0123 | 0.0116 | ||
| CKD | Visit 1 DBP | n | 243 | 65 | 27 | 34 | 98 | 8 | 14 | 7 |
| Mean(SD) | 96.8(10.2) | 94.9(8.6) | 92.3(6.9) | 96.9(10.4) | 93.3(7.6) | 98.9(8.7) | 94.6(7.5) | 100.1(7.8) | ||
| Median | 94.0 | 90.0 | 90.0 | 90.0 | 90.0 | 98.0 | 90.0 | 100.0 | ||
| Min, Max | 83,144 | 81,113 | 83,110 | 84,120 | 82,120 | 90,110 | 90,110 | 90,110 | ||
| Visit 2 DBP | Mean(SD) | 85.3(10.6) | 83.4(8.4) | 79.0(11.3) | 82.8(9.2) | 84.0(10.0) | 81.5(15.6) | 86.8(11.4) | 81.7(14.7) | |
| Median | 84.0 | 80.0 | 80.0 | 80.0 | 80.0 | 80.0 | 82.5 | 75.0 | ||
| Min, Max | 60,130 | 68,110 | 60,100 | 64,100 | 60,115 | 60,100 | 70,110 | 65,100 | ||
| Median | -10.0 | -10.0 | -16.0 | -10.0 | -10.0 | -12.5 | -10.0 | -20.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.0038 | 0.0762 | 0.0109 | ||
| Dyslipidemia+DM | Visit 1 SBP | n | 419 | 601 | 87 | 132 | 265 | 81 | 320 | 103 |
| Mean(SD) | 159.3(17.5) | 160.6(16.2) | 159.0(18.6) | 163.0(18.0) | 160.8(17.2) | 162.5(16.6) | 162.6(16.4) | 168.2(17.1) | ||
| Median | 160.0 | 160.0 | 160.0 | 161.5 | 160.0 | 160.0 | 160.0 | 170.0 | ||
| Min, Max | 122,200 | 121,200 | 125,200 | 130,200 | 121,200 | 127,200 | 121,200 | 121,200 | ||
| Visit 2 SBP | Mean(SD) | 140.1(16.0) | 139.4(15.8) | 141.3(15.9) | 142.5(18.5) | 142.1(17.4) | 142.4(15.9) | 140.8(16.9) | 143.0(17.8) | |
| Median | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | 140.0 | ||
| Min, Max | 103,191 | 70,200 | 108,180 | 101,200 | 90,200 | 112,180 | 96,192 | 110,200 | ||
| Change from Baseline (SBP) | Mean(SD) | -19.2(20.2) | -21.2(18.3) | -17.7(19.5) | -20.5(19.3) | -18.8(21.8) | -20.1(22.1) | -21.8(18.9) | -25.1(20.6) | |
| Median | -20.0 | -20.0 | -20.0 | -20.0 | -20.0 | -20.0 | -20.0 | -24.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| Dyslipidemia+DM | Visit 1 DBP | n | 419 | 601 | 87 | 132 | 265 | 81 | 320 | 103 |
| Mean(SD) | 92.9(7.3) | 94.2(8.0) | 94.2(8.5) | 93.8(6.9) | 93.4(7.9) | 94.1(7.0) | 94.7(8.3) | 96.4(8.6) | ||
| Median | 90.0 | 90.0 | 90.0 | 90.0 | 90.0 | 90.0 | 90.0 | 95.0 | ||
| Min, Max | 82,124 | 81,150 | 81,128 | 82,120 | 81,140 | 83,110 | 81,138 | 81,120 | ||
| Visit 2 DBP | Mean(SD) | 83.3(8.2) | 83.0(8.5) | 83.8(9.3) | 83.9(10.1) | 84.0(8.7) | 82.7(8.7) | 83.6(8.6) | 85.2(9.0) | |
| Median | 80.0 | 80.0 | 80.0 | 84.0 | 82.0 | 80.0 | 81.0 | 82.0 | ||
| Min, Max | 60,110 | 60,140 | 60,106 | 60,115 | 60,130 | 65,120 | 60,117 | 60,110 | ||
| Change from Baseline (DBP) | Mean(SD) | -9.6(9.9) | -11.2(9.9) | -10.4(11.1) | -9.9(11.0) | -9.4(10.1) | -11.4(9.4) | -11.1(10.1) | -11.2(11.0) | |
| Median | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | ||
| Dyslipidemia+CAD | Visit 1 SBP | n | 150 | 120 | 30 | 54 | 88 | 18 | 69 | 22 |
| Mean(SD) | 160.9(18.0) | 162.1(15.6) | 160.6(21.5) | 165.3(18.8) | 162.8(15.0) | 163.5(10.2) | 165.7(15.9) | 169.0(17.8) | ||
| Median | 160.0 | 160.0 | 160.0 | 165.5 | 160.0 | 168.0 | 166.0 | 172.0 | ||
| Min, Max | 122,200 | 126,200 | 126,200 | 130,200 | 128,200 | 147,180 | 126,200 | 126,190 | ||
| Visit 2 SBP | Mean(SD) | 142.8(16.5) | 139.5(16.3) | 139.8(18.7) | 142.1(16.6) | 140.6(17.7) | 137.5(14.7) | 138.1(17.8) | 146.2(16.2) | |
| Median | 140.0 | 137.0 | 140.0 | 140.0 | 140.0 | 138.0 | 138.0 | 141.5 | ||
| Min, Max | 110,194 | 110,190 | 110,180 | 110,180 | 100,200 | 113,170 | 96,190 | 120,190 | ||
| Change from Baseline (SBP) | Mean(SD) | -18.2(22.5) | -22.6(18.9) | -20.8(24.8) | -23.2(21.8) | -22.2(21.4) | -26.0(18.1) | -27.6(21.7) | -22.9(24.9) | |
| Median | -15.0 | -20.0 | -20.0 | -22.5 | -20.0 | -20.5 | -28.0 | -25.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.0003 | ||
| Dyslipidemia+CAD | Visit 1 DBP | n | 150 | 120 | 30 | 54 | 88 | 18 | 69 | 22 |
| Mean(SD) | 94.8(8.3) | 94.8(8.6) | 95.1(8.5) | 95.4(7.4) | 94.0(7.5) | 94.3(9.6) | 94.2(7.8) | 97.8(10.2) | ||
| Median | 90.0 | 90.5 | 91.0 | 92.5 | 90.0 | 90.0 | 90.0 | 100.0 | ||
| Min, Max | 82,120 | 82,135 | 82,110 | 83,116 | 81,120 | 82,120 | 82,120 | 83,120 | ||
| Visit 2 DBP | Mean(SD) | 85.3(9.8) | 82.7(7.7) | 83.6(8.0) | 84.5(10.0) | 82.8(9.1) | 80.4(8.4) | 81.6(8.5) | 87.7(13.1) | |
| Median | 84.0 | 80.0 | 80.0 | 81.5 | 80.0 | 80.0 | 80.0 | 88.0 | ||
| Min, Max | 60,140 | 70,103 | 60,104 | 65,115 | 68,130 | 62,90 | 60,110 | 69,120 | ||
| Change from Baseline (DBP) | Mean(SD) | -9.5(11.0) | -12.2(9.6) | -11.5(9.9) | -10.9(11.1) | -11.2(10.5) | -13.9(8.0) | -12.7(10.7) | -10.1(10.6) | |
| Median | -10.0 | -10.0 | -10.0 | -10.0 | -10.0 | -14.0 | -10.0 | -10.0 | ||
| P value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.0002 | ||
| Dyslipidemia+CKD | Visit 1 SBP | n | 85 | 33 | 15 | 23 | 45 | 3 | 10 | 4 |
| Mean(SD) | 165.5(18.2) | 161.1(15.4) | 165.5(22.6) | 164.0(17.9) | 161.9(17.0) | 157.7(19.1) | 165.3(17.5) | 166.5(12.5) | ||
| Median | 167.0 | 160.0 | 160.0 | 160.0 | 163.0 | 155.0 | 160.0 | 168.0 | ||
| Min, Max | 122,200 | 130,198 | 126,190 | 140,200 | 128,190 | 140,178 | 140,200 | 150,180 | ||
| Visit 2 SBP | Mean(SD) | 144.7(17.0) | 139.9(15.9) | 145.8(19.9) | 145.0(22.6) | 145.8(22.2) | 141.7(24.7) | 142.4(11.9) | 133.5(16.2) | |
| Median | 140.0 | 140.0 | 145.0 | 140.0 | 142.0 | 130.0 | 140.0 | 135.0 | ||
| Min, Max | 110,181 | 100,175 | 100,180 | 120,200 | 90,200 | 125,170 | 120,160 | 114,150 | ||
| Change from Baseline (SBP) | Mean(SD) | -20.8(21.3) | -21.2(21.7) | -19.7(26.7) | -19.0(17.5) | -16.1(25.2) | -16.0(40.8) | -22.9(17.1) | -33.0(22.8) | |
| Median | -20.0 | -20.0 | -20.0 | -17.0 | -14.0 | -30.0 | -20.0 | -40.0 | ||
| P value | <0.001 | <0.001 | 0.0127 | <0.001 | <0.001 | 0.5674 | 0.0022 | 0.0631 | ||
| Dyslipidemia+CKD | Visit 1 DBP | n | 85 | 33 | 15 | 23 | 45 | 3 | 10 | 4 |
| Mean(SD) | 94.9(8.3) | 94.7(9.4) | 92.6(7.6) | 96.5(10.4) | 92.5(7.8) | 103.3(11.5) | 94.4(6.9) | 101.0(8.4) | ||
| Median | 90.0 | 90.0 | 90.0 | 90.0 | 90.0 | 110.0 | 90.0 | 102.0 | ||
| Min, Max | 83,116 | 81,113 | 84,110 | 84,120 | 82,120 | 90,110 | 90,110 | 90,110 | ||
| Visit 2 DBP | Mean(SD) | 83.1(9.0) | 82.8(8.4) | 80.7(13.1) | 82.5(9.6) | 83.4(9.4) | 86.7(18.9) | 81.5(5.8) | 75.5(10.5) | |
| Median | 80.0 | 80.0 | 80.0 | 80.0 | 80.0 | 95.0 | 80.0 | 73.5 | ||
| Min, Max | 67,110 | 70,110 | 60,100 | 69,100 | 60,103 | 65,100 | 70,90 | 65,90 | ||
| Change from Baseline (DBP) | Mean(SD) | -11.8(10.9) | -11.9(10.0) | -11.9(16.9) | -14.0(9.8) | -9.1(10.6) | -16.7(7.6) | -12.9(10.3) | -25.5(11.7) | |
| Median | -10.0 | -11.0 | -9.0 | -10.0 | -8.0 | -15.0 | -10.0 | -27.0 | ||
| P value | <0.001 | <0.001 | 0.0164 | <0.001 | <0.001 | 0.0634 | 0.0033 | 0.0222 | ||
| DM+CAD | Visit 1 SBP | n | 79 | 75 | 18 | 24 | 47 | 9 | 33 | 13 |
| Mean(SD) | 162.0(18.6) | 161.6(15.6) | 160.5(21.2) | 169.3(17.8) | 164.2(15.2) | 158.2(8.1) | 166.0(16.9) | 169.8(17.1) | ||
| Median | 162.0 | 160.0 | 160.0 | 169.0 | 160.0 | 159.0 | 165.0 | 174.0 | ||
| Min, Max | 122,200 | 130,200 | 130,200 | 138,200 | 140,200 | 150,171 | 136,200 | 135,190 | ||
| Visit 2 SBP | Mean(SD) | 142.9(18.8) | 141.4(15.7) | 144.9(14.1) | 146.7(19.4) | 143.2(20.4) | 131.2(11.4) | 144.5(18.1) | 143.9(12.4) | |
| Median | 142.0 | 140.0 | 143.0 | 150.0 | 137.0 | 136.0 | 140.0 | 140.0 | ||
| Min, Max | 94,192 | 110,180 | 120,170 | 110,180 | 120,200 | 113,150 | 110,190 | 120,166 | ||
| Change from Baseline (SBP) | Mean(SD) | -19.1(23.4) | -20.2(18.8) | -15.6(22.6) | -22.6(21.8) | -21.0(24.4) | -27.0(18.4) | -21.5(19.2) | -25.9(21.9) | |
| Median | -18.0 | -19.0 | -17.0 | -26.5 | -22.0 | -20.0 | -20.0 | -20.0 | ||
| P value | <0.001 | <0.001 | 0.0094 | <0.001 | <0.001 | 0.0023 | <0.001 | 0.0011 | ||
| DM+CAD | Visit 1 DBP | n | 79 | 75 | 18 | 24 | 47 | 9 | 33 | 13 |
| Mean(SD) | 93.2(7.5) | 95.9(8.8) | 95.0(9.8) | 96.2(8.3) | 93.0(6.9) | 90.3(2.9) | 93.2(7.2) | 94.0(6.3) | ||
| Median | 90.0 | 96.0 | 91.0 | 94.0 | 90.0 | 90.0 | 90.0 | 94.0 | ||
| Min, Max | 81,118 | 82,135 | 82,110 | 84,116 | 82,116 | 87,96 | 82,110 | 83,100 | ||
| Visit 2 DBP | Mean(SD) | 83.9(7.8) | 83.4(7.5) | 85.3(6.4) | 85.8(12.5) | 84.2(10.2) | 77.3(6.4) | 83.4(8.5) | 86.4(8.6) | |
| Median | 82.0 | 80.0 | 85.0 | 86.0 | 80.0 | 76.0 | 81.0 | 88.0 | ||
| Min, Max | 60,102 | 70,103 | 74,99 | 65,115 | 70,130 | 70,90 | 66,110 | 69,100 | ||
| Change from Baseline (DBP) | Mean(SD) | -9.3(9.0) | -12.5(8.3) | -9.7(8.3) | -10.4(14.9) | -8.7(8.5) | -13.0(5.3) | -9.8(9.7) | -7.6(6.5) | |
| Median | -10.0 | -11.0 | -10.0 | -10.0 | -10.0 | -13.0 | -10.0 | -10.0 | ||
| P value | <0.001 | <0.001 | 0.0001 | 0.0023 | <0.001 | <0.001 | <0.001 | 0.0011 | ||
| DM+CKD | Visit 1 SBP | n | 72 | 30 | 9 | 17 | 44 | 7 | 12 | 3 |
| Mean(SD) | 165.2(17.6) | 162.5(15.9) | 167.4(18.5) | 166.2(17.0) | 162.5(16.7) | 157.3(11.3) | 161.9(17.3) | 165.3(5.0) | ||
| Median | 170.0 | 168.5 | 170.0 | 160.0 | 160.0 | 155.0 | 156.5 | 166.0 | ||
| Min, Max | 122,200 | 130,198 | 136,190 | 140,200 | 128,200 | 140,178 | 140,200 | 160,170 | ||
| Visit 2 SBP | Mean(SD) | 147.3(18.3) | 144.9(16.4) | 149.0(12.9) | 151.1(22.7) | 148.6(22.6) | 139.7(26.9) | 147.8(15.1) | 133.7(23.7) | |
| Median | 146.5 | 140.0 | 145.0 | 147.0 | 148.0 | 130.0 | 145.0 | 127.0 | ||
| Min, Max | 110,196 | 108,180 | 134,170 | 120,200 | 90,200 | 107,180 | 120,170 | 114,160 | ||
| Change from Baseline (SBP) | Mean(SD) | -17.9(22.2) | -17.6(20.7) | -18.4(26.2) | -15.1(13.1) | -13.8(25.8) | -17.6(32.9) | -14.1(21.1) | -31.7(27.8) | |
| Median | -20.0 | -20.0 | -20.0 | -15.0 | -10.0 | -30.0 | -14.5 | -43.0 | ||
| P value | <0.001 | <0.001 | 0.0679 | 0.0002 | 0.0009 | 0.2069 | 0.0409 | 0.1871 | ||
| DM+CKD | Visit 1 DBP | n | 72 | 30 | 9 | 17 | 44 | 7 | 12 | 3 |
| Mean(SD) | 93.5(7.8) | 94.1(8.5) | 91.6(6.0) | 95.0(9.9) | 90.5(6.1) | 98.7(9.4) | 94.5(7.8) | 98.0(7.2) | ||
| Median | 90.0 | 90.0 | 90.0 | 90.0 | 90.0 | 96.0 | 90.0 | 100.0 | ||
| Min, Max | 83,115 | 82,110 | 84,100 | 86,120 | 82,110 | 90,110 | 90,110 | 90,104 | ||
| Visit 2 DBP | Mean(SD) | 83.8(8.5) | 82.1(8.3) | 82.1(12.4) | 84.1(8.6) | 82.3(9.2) | 84.6(14.0) | 87.5(12.2) | 80.0(18.0) | |
| Median | 80.5 | 80.0 | 80.0 | 80.0 | 80.0 | 80.0 | 85.0 | 75.0 | ||
| Min, Max | 69,110 | 69,100 | 65,100 | 69,100 | 60,100 | 65,100 | 70,110 | 65,100 | ||
| Change from Baseline (DBP) | Mean(SD) | -9.8(9.6) | -12.0(11.6) | -9.4(16.1) | -10.9(8.3) | -8.3(10.3) | -14.1(7.6) | -7.0(16.3) | -18.0(15.7) | |
| Median | -10.0 | -10.0 | -4.0 | -10.0 | -8.0 | -10.0 | -10.0 | -25.0 | ||
| P value | <0.001 | <0.001 | 0.1159 | <0.001 | <0.001 | 0.0027 | 0.1640 | 0.1857 | ||
| CKD+CAD | Visit 1 SBP | n | 22 | 7 | 2 | 7 | 10 | 1 | 3 | 1 |
| Mean(SD) | 160.8(17.9) | 154.6(13.2) | 131.0(7.1) | 167.6(18.8) | 165.9(11.9) | 160.0(.) | 186.7(11.5) | 180.0(.) | ||
| Median | 160.0 | 150.0 | 131.0 | 180.0 | 170.0 | 160.0 | 180.0 | 180.0 | ||
| Min, Max | 122,190 | 140,171 | 126,136 | 140,187 | 150,190 | 160,160 | 180,200 | 180,180 | ||
| Visit 2 SBP | Mean(SD) | 141.5(18.3) | 140.9(21.3) | 146.5(33.2) | 146.4(18.8) | 145.7(30.5) | 120.0(.) | 156.7(5.8) | 143.0(.) | |
| Median | 140.0 | 130.0 | 146.5 | 140.0 | 145.0 | 120.0 | 160.0 | 143.0 | ||
| Min, Max | 120,172 | 120,180 | 123,170 | 120,178 | 100,200 | 120,120 | 150,160 | 143,143 | ||
| Change from Baseline (SBP) | Mean(SD) | -19.3(24.2) | -13.7(28.8) | 15.5(26.2) | -21.1(23.9) | -20.2(33.6) | -40.0(.) | -30.0(17.3) | -37.0(.) | |
| Median | -20.0 | -20.0 | 15.5 | -11.0 | -25.0 | -40.0 | -20.0 | -37.0 | ||
| P value | 0.0012 | 0.2552 | 0.5560 | 0.0576 | 0.0899 | 0.0955 | ||||
| CKD+CAD | Visit 1 DBP | n | 22 | 7 | 2 | 7 | 10 | 1 | 3 | 1 |
| Mean(SD) | 94.7(7.3) | 91.7(8.5) | 94.5(14.8) | 98.1(10.9) | 90.1(4.0) | 90.0(.) | 96.7(11.5) | 110.0(.) | ||
| Median | 90.0 | 90.0 | 94.5 | 91.0 | 90.0 | 90.0 | 90.0 | 110.0 | ||
| Min, Max | 86,110 | 83,110 | 84,105 | 90,116 | 84,100 | 90,90 | 90,110 | 110,110 | ||
| Visit 2 DBP | Mean(SD) | 81.7(7.6) | 84.3(9.8) | 82.5(3.5) | 81.0(3.7) | 80.8(7.5) | 80.0(.) | 86.7(5.8) | 72.0(.) | |
| Median | 80.0 | 80.0 | 82.5 | 80.0 | 80.0 | 80.0 | 90.0 | 72.0 | ||
| Min, Max | 70,100 | 70,100 | 80,85 | 77,89 | 68,90 | 80,80 | 80,90 | 72,72 | ||
| Change from Baseline (DBP) | Mean(SD) | -13.0(9.7) | -7.4(10.9) | -12.0(11.3) | -17.1(8.6) | -9.3(10.2) | -10.0(.) | -10.0(10.0) | -38.0(.) | |
| Median | -10.0 | -8.0 | -12.0 | -14.0 | -9.0 | -10.0 | -10.0 | -38.0 | ||
| P value | <0.001 | 0.1203 | 0.3743 | 0.0019 | 0.0184 | 0.2254 | ||||
| Dyslipidemia+DM+CAD | Visit 1 SBP | n | 66 | 57 | 16 | 21 | 43 | 7 | 29 | 11 |
| Mean(SD) | 160.9(17.9) | 162.1(13.6) | 161.2(22.4) | 172.9(15.9) | 163.2(14.9) | 158.9(8.9) | 166.5(15.6) | 168.7(18.2) | ||
| Median | 162.0 | 162.0 | 160.0 | 170.0 | 160.0 | 159.0 | 168.0 | 174.0 | ||
| Min, Max | 122,200 | 130,190 | 130,200 | 140,200 | 140,200 | 150,171 | 139,200 | 135,190 | ||
| Visit 2 SBP | Mean(SD) | 142.8(17.6) | 139.9(15.6) | 145.2(14.9) | 150.5(17.4) | 142.6(20.0) | 132.1(12.1) | 144.4(19.3) | 141.4(11.2) | |
| Median | 141.0 | 137.0 | 143.5 | 150.0 | 137.0 | 136.0 | 140.0 | 140.0 | ||
| Min, Max | 110,180 | 110,180 | 120,170 | 110,180 | 120,200 | 113,150 | 110,190 | 120,160 | ||
| Change from Baseline (SBP) | Mean(SD) | -18.1(24.0) | -22.2(16.6) | -16.0(24.0) | -22.4(23.3) | -20.6(24.5) | -26.7(20.1) | -22.0(18.8) | -27.4(23.6) | |
| Median | -13.0 | -20.0 | -20.0 | -26.0 | -22.0 | -20.0 | -20.0 | -30.0 | ||
| P value | <0.001 | <0.001 | 0.0175 | 0.0003 | <0.001 | 0.0126 | <0.001 | 0.0032 | ||
| Dyslipidemia+DM+CAD | Visit 1 DBP | n | 66 | 57 | 16 | 21 | 43 | 7 | 29 | 11 |
| Mean(SD) | 93.1(6.9) | 95.5(9.0) | 93.8(9.5) | 97.6(7.8) | 92.7(7.0) | 89.6(2.3) | 92.6(6.7) | 94.0(6.3) | ||
| Median | 90.0 | 96.0 | 90.0 | 96.0 | 90.0 | 90.0 | 90.0 | 94.0 | ||
| Min, Max | 82,110 | 83,135 | 82,110 | 90,116 | 82,116 | 87,94 | 82,110 | 83,100 | ||
| Visit 2 DBP | Mean(SD) | 83.8(7.8) | 82.9(7.8) | 84.9(6.7) | 87.0(12.8) | 84.1(10.5) | 75.1(4.6) | 83.1(8.9) | 85.9(9.3) | |
| Median | 82.5 | 80.0 | 82.0 | 89.0 | 80.0 | 75.0 | 80.0 | 86.0 | ||
| Min, Max | 60,100 | 70,103 | 74,99 | 65,115 | 70,130 | 70,82 | 66,110 | 69,100 | ||
| Change from Baseline (DBP) | Mean(SD) | -9.3(9.0) | -12.6(8.5) | -8.8(8.3) | -10.6(15.6) | -8.5(8.6) | -14.4(5.0) | -9.5(10.1) | -8.1(6.6) | |
| Median | -10.0 | -11.0 | -9.0 | -10.0 | -10.0 | -16.0 | -10.0 | -10.0 | ||
| P value | <0.001 | <0.001 | 0.0007 | 0.0054 | <0.001 | 0.0003 | <0.001 | 0.0023 | ||
| Dyslipidemia+DM+CKD | Visit 1 SBP | n | 38 | 18 | 8 | 13 | 27 | 3 | 8 | 2 |
| Mean(SD) | 164.7(18.7) | 161.4(16.6) | 166.6(19.6) | 170.4(16.8) | 158.1(14.6) | 157.7(19.1) | 161.6(14.3) | 168.0(2.8) | ||
| Median | 170.0 | 166.0 | 165.0 | 166.0 | 157.0 | 155.0 | 160.0 | 168.0 | ||
| Min, Max | 122,200 | 130,198 | 136,190 | 146,200 | 128,190 | 140,178 | 140,180 | 166,170 | ||
| Visit 2 SBP | Mean(SD) | 144.0(16.0) | 143.4(13.5) | 150.9(12.4) | 157.2(22.1) | 146.6(23.4) | 141.7(24.7) | 143.0(13.4) | 120.5(9.2) | |
| Median | 141.0 | 140.0 | 147.5 | 160.0 | 140.0 | 130.0 | 140.0 | 120.5 | ||
| Min, Max | 120,180 | 125,175 | 140,170 | 122,200 | 90,200 | 125,170 | 120,160 | 114,127 | ||
| Change from Baseline (SBP) | Mean(SD) | -20.7(23.0) | -18.0(18.9) | -15.8(26.7) | -13.2(13.0) | -11.5(25.8) | -16.0(40.8) | -18.6(12.5) | -47.5(6.4) | |
| Median | -20.0 | -20.0 | -15.0 | -10.0 | -10.0 | -30.0 | -19.5 | -47.5 | ||
| P value | <0.001 | 0.0008 | 0.1388 | 0.0034 | 0.0292 | 0.5674 | 0.0039 | 0.0601 | ||
| Dyslipidemia+DM+CKD | Visit 1 DBP | n | 38 | 18 | 8 | 13 | 27 | 3 | 8 | 2 |
| Mean(SD) | 93.2(8.2) | 93.2(8.7) | 91.0(6.1) | 96.5(11.0) | 89.0(4.5) | 103.3(11.5) | 94.3(7.3) | 97.0(9.9) | ||
| Median | 90.0 | 90.0 | 90.0 | 91.0 | 90.0 | 110.0 | 90.0 | 97.0 | ||
| Min, Max | 83,110 | 83,110 | 84,100 | 86,120 | 82,105 | 90,110 | 90,110 | 90,104 | ||
| Visit 2 DBP | Mean(SD) | 82.7(8.1) | 81.4(7.3) | 82.4(13.2) | 84.6(9.6) | 81.4(8.9) | 86.7(18.9) | 81.3(6.4) | 70.0(7.1) | |
| Median | 80.0 | 80.0 | 80.0 | 80.0 | 80.0 | 95.0 | 80.0 | 70.0 | ||
| Min, Max | 69,110 | 70,100 | 65,100 | 69,100 | 60,100 | 65,100 | 70,90 | 65,75 | ||
| Change from Baseline (DBP) | Mean(SD) | -10.5(10.4) | -11.7(11.5) | -8.6(17.0) | -11.9(9.0) | -7.7(10.3) | -16.7(7.6) | -13.0(11.6) | -27.0(2.8) | |
| Median | -10.0 | -13.5 | -4.0 | -10.0 | -7.0 | -15.0 | -10.0 | -27.0 | ||
| P value | <0.001 | 0.0005 | 0.1939 | 0.0004 | 0.0007 | 0.0634 | 0.0158 | 0.0471 | ||
| Dyslipidemia+CAD+CKD | Visit 1 SBP | n | 17 | 5 | 2 | 5 | 8 | 2 | 1 | |
| Mean(SD) | 159.4(18.0) | 160.4(10.5) | 131.0(7.1) | 170.6(17.1) | 162.4(9.1) | 180.0(0.0) | 180.0(.) | |||
| Median | 160.0 | 162.0 | 131.0 | 180.0 | 166.5 | 180.0 | 180.0 | |||
| Min, Max | 122,190 | 149,171 | 126,136 | 146,187 | 150,170 | 180,180 | 180,180 | |||
| Visit 2 SBP | Mean(SD) | 141.1(19.5) | 137.2(13.0) | 146.5(33.2) | 149.0(22.4) | 139.6(31.4) | 160.0(0.0) | 143.0(.) | ||
| Median | 140.0 | 130.0 | 146.5 | 152.0 | 132.0 | 160.0 | 143.0 | |||
| Min, Max | 120,172 | 130,160 | 123,170 | 120,178 | 100,200 | 160,160 | 143,143 | |||
| Change from Baseline (SBP) | Mean(SD) | -18.4(25.6) | -23.2(20.1) | 15.5(26.2) | -21.6(25.6) | -22.8(37.2) | -20.0(0.0) | -37.0(.) | ||
| Median | -20.0 | -32.0 | 15.5 | -11.0 | -30.0 | -20.0 | -37.0 | |||
| P value | 0.0093 | 0.0614 | 0.5560 | 0.1320 | 0.1277 | <0.001 | ||||
| Dyslipidemia+CAD+CKD | Visit 1 DBP | n | 17 | 5 | 2 | 5 | 8 | 2 | 1 | |
| Mean(SD) | 94.5(7.9) | 92.4(10.3) | 94.5(14.8) | 95.4(11.5) | 90.1(4.5) | 90.0(0.0) | 110.0(.) | |||
| Median | 90.0 | 90.0 | 94.5 | 90.0 | 90.0 | 90.0 | 110.0 | |||
| Min, Max | 86,110 | 83,110 | 84,105 | 90,116 | 84,100 | 90,90 | 110,110 | |||
| Visit 2 DBP | Mean(SD) | 82.6(7.6) | 86.0(8.9) | 82.5(3.5) | 81.4(4.5) | 79.8(7.7) | 85.0(7.1) | 72.0(.) | ||
| Median | 80.0 | 80.0 | 82.5 | 80.0 | 80.0 | 85.0 | 72.0 | |||
| Min, Max | 70,100 | 80,100 | 80,85 | 77,89 | 68,90 | 80,90 | 72,72 | |||
| Change from Baseline (DBP) | Mean(SD) | -11.9(9.0) | -6.4(11.1) | -12.0(11.3) | -14.0(7.5) | -10.4(11.0) | -5.0(7.1) | -38.0(.) | ||
| Median | -10.0 | -8.0 | -12.0 | -10.0 | -9.0 | -5.0 | -38.0 | |||
| P value | <0.001 | 0.2653 | 0.3743 | 0.0141 | 0.0322 | 0.5000 | ||||
| DM+CAD+CKD | Visit 1 SBP | n | 9 | 5 | 1 | 3 | 7 | 1 | 3 | |
| Mean(SD) | 160.1(23.6) | 150.0(12.7) | 136.0(.) | 175.7(14.0) | 161.3(9.3) | 160.0(.) | 186.7(11.5) | |||
| Median | 170.0 | 149.0 | 136.0 | 180.0 | 163.0 | 160.0 | 180.0 | |||
| Min, Max | 122,189 | 140,171 | 136,136 | 160,187 | 150,170 | 160,160 | 180,200 | |||
| Visit 2 SBP | Mean(SD) | 144.8(21.3) | 145.2(24.4) | 170.0(.) | 163.3(13.3) | 149.6(30.4) | 120.0(.) | 156.7(5.8) | ||
| Median | 147.0 | 136.0 | 170.0 | 160.0 | 150.0 | 120.0 | 160.0 | |||
| Min, Max | 120,172 | 120,180 | 170,170 | 152,178 | 120,200 | 120,120 | 150,160 | |||
| Change from Baseline (SBP) | Mean(SD) | -15.3(32.3) | -4.8(29.9) | 34.0(.) | -12.3(19.7) | -11.7(34.4) | -40.0(.) | -30.0(17.3) | ||
| Median | -10.0 | -19.0 | 34.0 | -2.0 | -6.0 | -40.0 | -20.0 | |||
| P value | 0.1918 | 0.7376 | 0.3907 | 0.4021 | 0.0955 | |||||
| DM+CAD+CKD | Visit 1 DBP | n | 9 | 5 | 1 | 3 | 7 | 1 | 3 | |
| Mean(SD) | 91.4(5.1) | 88.8(3.3) | 84.0(.) | 99.0(14.7) | 88.7(2.2) | 90.0(.) | 96.7(11.5) | |||
| Median | 90.0 | 90.0 | 84.0 | 91.0 | 90.0 | 90.0 | 90.0 | |||
| Min, Max | 86,100 | 83,91 | 84,84 | 90,116 | 84,90 | 90,90 | 90,110 | |||
| Visit 2 DB | Mean(SD) | 80.9(5.3) | 84.0(11.4) | 80.0(.) | 82.0(6.2) | 82.9(7.2) | 80.0(.) | 86.7(5.8) | ||
| Median | 80.0 | 80.0 | 80.0 | 80.0 | 82.0 | 80.0 | 90.0 | |||
| Min, Max | 70,90 | 70,100 | 80,80 | 77,89 | 70,90 | 80,80 | 80,90 | |||
| Change from Baseline (DBP) | Mean(SD) | -10.6(7.9) | -4.8(11.3) | -4.0(.) | -17.0(8.9) | -5.9(7.6) | -10.0(.) | -10.0(10.0) | ||
| Median | -10.0 | -3.0 | -4.0 | -14.0 | -4.0 | -10.0 | -10.0 | |||
| P value | 0.0039 | 0.3977 | 0.0803 | 0.0870 | 0.2254 |