FIGURE 2.

ORS in the mITT population. LS mean ORS in the mITT population based on MMRM in (A) RADIUS‐R and (B) RADIUS‐P. Error bars are 95% confidence intervals. The ORS was scored relative to baseline at each assessment and summed for a possible range of −4 (worsening in all components) to +4 (improvements in all components). LS = least squares; mITT = modified intent‐to‐treat; MMRM = mixed‐effect model for repeated measures; ORS = Overall Response Score. [Color figure can be viewed at www.annalsofneurology.org]