Table 3. Validation of male and female nSR and female cAF human atrial models:
Model outputs for action potential duration at 90% repolarization (APD90), APD50, resting membrane potential (RMP), AP amplitude (APA), maximum upstroke velocity (Vmax), plateau voltage (VPLT), and Ca2+ transient amplitude (CaTAmp) compared to experimental results from (Ravens, 2018; Heijman et al., 2020; Pecha et al., 2023). Symbols indicating significant differences between groups (p < 0.05), were as reported in Pecha et al., 2023 and Ravens, 2018.
| nSR | ||||||
|---|---|---|---|---|---|---|
| Male | Female | M vs. F | Male | Female | M vs. F | |
| Biomarker | Model | Experiment | ||||
| APD90 (ms) | 299.69 | 291.96 | = | 319.91±2.60 | 314.80±4.19 | N.S. (Ravens, 2018; Pecha et al., 2023) |
| APD50 (ms) | 108.96 | 119.63 | < | 136.98±2.39 | 146.87±3.85 | < (Ravens, 2018; Pecha et al., 2023) |
| RMP (mV) | −78.45 | −77.21 | < | −74.58±0.24 | −73.16±0.39 | < (Ravens, 2018; Pecha et al., 2023) |
| APA (mV) | 114.73 | 113.83 | > | 95.50±0.47 | 92.8±0.75 | > (Ravens, 2018; Pecha et al., 2023) |
| Vmax (V/S) | 237.02 | 204.80 | > | 234.04±4.50 | 212.07±7.27 | > (Ravens, 2018; Pecha et al., 2023) |
| VPLT (mV) | −11.09 | −7.86 | < | −16.78±0.57 | −15.11±0.92 |
N.S. (Pecha et al., 2023) < (Ravens, 2018) |
| CaTAmp (nM) | 259.96 | 275.21 | < | 217.11±135.64 | 261.63±175.19 | N.S. (Heijman et al., 2020) |
| cAF | ||||||
| Male | Female | M vs. F | Male | Female | M vs. F | |
| Biomarker | Model | Experiment | ||||
| APD90 (ms) | 230.55 | 219.13 | = | 216.01±3.34 | 222.19±4.30 | N.S. (Ravens, 2018; Pecha et al., 2023) |
| APD50 (ms) | 101.47 | 102.57 | = | 99.19±3.09 | 101.79±3.98 | N.S. (Ravens, 2018; Pecha et al., 2023) |
| RMP (mV) | −82.51 | −82.32 | = | −77.57±0.30 | −77.27±0.39 | N.S. (Ravens, 2018; Pecha et al., 2023) |
| APA (mV) | 125.57 | 123.42 | = | 102.20±0.59 | 100.98±0.77 | N.S. (Ravens, 2018; Pecha et al., 2023) |
| Vmax (V/s) | 239.70 | 212.64 | > | 248.23±5.65 | 233.1±7.28 |
N.S. (Pecha et al., 2023) > (Ravens, 2018) |
| VPLT (mV) | −5.97 | −5.83 | = | −5.56±0.72 | −6.63±0.93 | N.S. (Ravens, 2018; Pecha et al., 2023) |
| CaTAmp (nM) | 170.53 | 203.70 | < | / | / | / |