Fig. 1. Study flow from treatment randomisation to the 6-month follow-up (end of the original trial period), through to the 4-year follow-up assessment.

Note that some participants who did not complete the initial 6-month follow-up did return for the 4YFU. DXA, whole-body dual-energy X-ray absorptiometry scans; FMT faecal microbiota transplantation.