TABLE 3.
Trend analysis of re‐compensation in decompensated PBC patients based on LMR.
| Variable | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| Model A | Model B | Model C | ||||||
| HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | HR (95% CI) | p | |
| LMR (quartile) | ||||||||
| Quantile 1 | Reference | < 0.001 | Reference | < 0.001 | Reference | < 0.001 | Reference | < 0.001 |
| Quantile 2 | 1.308 (0.534–3.2) | 0.557 | 1.200 (0.487–2.958) | 0.692 | 1.140 (0.461–2.817) | 0.776 | 1.695 (0.614–4.681) | 0.309 |
| Quantile 3 | 3.376 (1.547–7.365) | 0.002 | 2.951 (1.345–6.473) | 0.007 | 2.913 (1.324–6.409) | 0.008 | 3.356 (1.361–8.275) | 0.009 |
| Quantile 4 | 5.978 (2.845–12.561) | < 0.001 | 4.947 (2.325–10.527) | < 0.001 | 4.700 (2.197–10.056) | < 0.001 | 4.925 (2.041–11.884) | < 0.001 |
| p for trend | 1.924 (1.565–2.366) | < 0.001 | 1.819 (1.475–2.244) | < 0.001 | 1.798 (1.455–2.223) | < 0.001 | 1.680 (1.334–2.115) | < 0.001 |
Note: Model A: Adjusted for age, sex, adjusted BMI and LMR. Model B: Adjusted for age, sex, adjusted BMI, hypertension, coronary artery disease, diabetes mellitus and LMR. Model C: Adjusted for age, sex, adjusted BMI, hypertension, coronary artery disease, diabetes mellitus, multiple (≥ 2) decompensation events, total bilirubin, total bile acids, ALT, AST, ALP, GGT, anti‐sp100 antibody, anti‐gp210 antibody and LMR.