Table 4. Co-occurring mutations, epitope escape mutants, and the associated frequency of occurrence and relative fitness of NS3 region of subject THGS0684MX.

Time	Viral load (IU/ml)	Frequency	Relative fitness	1325SILGIGTAL1333Mutations	Co-occurring mutations*
2DPI	140,200	87.9%	1.000
		4.8%	0.148		G1076W
		3.2%	1.000
		3%	0.155		G1076R
		1.1%	0.022		G1076W	Y1521C
58DPI	19,932	74.2%	1.000
		10.8%	1.000
		8.4%	0.322
		5.5%	0.162		M1649T
		1%	0.322		S1289G
184DPI	221,964	90.9%	1.042	A1332V †	P1496S
		9.1%	0.157	A1332V	D1316G	P1496S

^*Only non-synonymous mutations are shown.

^†Bold - indicate escape variants with fitness estimate ≥1.