Table 2.
Patient Preoperative MRI Characteristics: Comparison between POD and NPOD Groups
| MRI Parameter | POD (n = 19) | NPOD (n = 31) | P-value† |
|---|---|---|---|
| BBB Ktrans (× 10–3 min−1), median (IQR) | |||
| Hippocampus | 5.36 (3.99, 8.39) | 3.89 (3.40, 4.68) | 0.048 |
| Thalamus | 4.80 (3.58, 6.62) | 3.55 (3.05, 4.57) | 0.034 |
| Frontal lobe | 5.12 (3.77, 5.89) | 3.80 (3.13, 6.29) | 0.268 |
| Temporal lobe | 3.85 (2.82, 5.11) | 3.29 (2.79, 3.71) | 0.227 |
| Volume (cm3), mean (SD) | |||
| Total Brain Volume | 1445 (125) | 1450 (139) | 0.893 |
| Hippocampal Volume | 7.05 (0.93) | 8.12 (1.01) | 0.003 |
| Thalamic Volume | 6.81 (0.63) | 7.53 (0.95) | 0.008 |
| Leukoaraiosis (Fazekas grade ≥ 2), n (%) | 3 (15.8) | 8 (25.8) | 0.498 |
Data are presented as mean (SD) or median (IQR) for continuous variables and n (%) for categorical variables. †P-values for group comparisons of Ktrans and Volume are adjusted for multiple comparisons using the False Discovery Rate (FDR) method. Bold P-values indicate statistical significance (PFDR < 0.05)
POD postoperative delirium, NPOD Non-POD, MRI Magnetic Resonance Imaging, BBB blood–brain barrier, Ktrans volume transfer constant, IQR interquartile range