Table 2. Summary of GSEA results with FDR ≤ 0.25.
| Gene set | FDR |
|---|---|
| Data set: Lymphoblast cell lines | |
| Enriched in males | |
| chrY | <0.001 |
| chrYp11 | <0.001 |
| chrYq11 | <0.001 |
| Testis expressed genes | 0.012 |
| Enriched in females | |
| X inactivation genes | <0.001 |
| Female reproductive tissue expressed genes | 0.045 |
| Data set: p53 status in NCl-60 cell lines | |
| Enriched in p53 mutant | |
| Ras signaling pathway | 0.171 |
| Enriched in p53 wild type | |
| Hypoxia and p53 in the cardiovascular system | <0.001 |
| Stress induction of HSP regulation | <0.001 |
| p53 signaling pathway | <0.001 |
| p53 up-regulated genes | 0.013 |
| Radiation sensitivity genes | 0.078 |
| Data set: Acute leukemias | |
| Enriched in ALL | |
| chr6q21 | 0.011 |
| chr5q31 | 0.046 |
| chr13q14 | 0.057 |
| chr14q32 | 0.082 |
| chr17q23 | 0.071 |
| Data set: Lung cancer outcome, Boston study | |
| Enriched in poor outcome | |
| Hypoxia and p53 in the cardiovascular system | 0.050 |
| Aminoacyl tRNA biosynthesis | 0.144 |
| Insulin upregulated genes | 0.118 |
| tRNA synthetases | 0.157 |
| Leucine deprivation down-regulated genes | 0.144 |
| Telomerase up-regulated genes | 0.128 |
| Glutamine deprivation down-regulated genes | 0.146 |
| Cell cycle checkpoint | 0.216 |
| Data set: Lung cancer outcome, Michigan study | |
| Enriched in poor outcome | |
| Glycolysis gluconeogenesis | 0.006 |
| vegf pathway | 0.028 |
| Insulin up-regulated genes | 0.147 |
| Insulin signalling | 0.170 |
| Telomerase up-regulated genes | 0.188 |
| Glutamate metabolism | 0.200 |
| Ceramide pathway | 0.204 |
| p53 signalling | 0.179 |
| tRNA synthetases | 0.225 |
| Breast cancer estrogen signalling | 0.250 |
| Aminoacyl tRNA biosynthesis | 0.229 |
For detailed results, see Table 4, which is published as supporting information on the PNAS web site.